Descripción de un caso: liposarcoma de mama radioinducido

IF 0.1 Q4 OBSTETRICS & GYNECOLOGY

Clinica e Investigacion en Ginecologia y Obstetricia Pub Date : 2024-09-30 DOI:10.1016/j.gine.2024.100998

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Abstract

Main symptoms and/or clinical findings

Breast sarcoma is a very rare entity that constitutes only 1% of all primary malignant breast tumors. It has a very poor prognosis with a high risk of recurrence. In this article, we present the case of a patient diagnosed with breast liposarcoma after having received radiotherapy for a previous breast carcinoma.

Main diagnoses

Due to the rarity of breast liposarcoma, it is important to make an adequate differential diagnosis. In our case, the study of overexpression of the MDM2 and/or CDK4 proteins allowed us to establish the definitive diagnosis.

Therapeutic interventions and results

The patient in our case underwent surgery, obtaining tumor-free margins with a favorable subsequent evolution. She currently has 18 months of disease-free survival.

Conclusion

The treatment of breast liposarcoma is mainly surgical since this sarcoma has a poor response to both chemotherapy and radiotherapy. The correct tumor resection is the most important prognostic factor for local control of the disease and long-term survival.

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病例报告：放射性诱导的乳腺脂肪肉瘤

主要症状和/或临床表现乳腺肉瘤是一种非常罕见的肿瘤，仅占所有原发性恶性乳腺肿瘤的 1%。它的预后很差，复发风险很高。由于乳腺脂肪肉瘤的罕见性，进行充分的鉴别诊断非常重要。在我们的病例中，通过对 MDM2 和/或 CDK4 蛋白过度表达的研究，我们确定了明确的诊断。治疗干预和结果我们病例中的患者接受了手术，获得了无肿瘤边缘，随后的病情发展良好。结论乳腺脂肪肉瘤的治疗以手术为主，因为这种肉瘤对化疗和放疗的反应都很差。正确的肿瘤切除是疾病局部控制和长期生存的最重要预后因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinica e Investigacion en Ginecologia y Obstetricia OBSTETRICS & GYNECOLOGY-

CiteScore

0.20

自引率

0.00%

发文量

期刊介绍： Una excelente publicación para mantenerse al día en los temas de máximo interés de la ginecología de vanguardia. Resulta idónea tanto para el especialista en ginecología, como en obstetricia o en pediatría, y está presente en los más prestigiosos índices de referencia en medicina.