Epidemiological investigation and analysis of the infection of porcine circovirus in Xinjiang.

IF 5.4 3区材料科学 Q2 CHEMISTRY, PHYSICAL

ACS Applied Energy Materials Pub Date : 2024-09-27 DOI:10.1186/s12985-024-02504-w

Kai Yang, Zunbao Wang, Xinyu Wang, Mingfang Bi, Suhua Hu, Kaijie Li, Xiaomei Pan, Yuan Wang, Dan Ma, Xiaobing Mo

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Abstract

Porcine circoviruses, particularly porcine circovirus type 2 (PCV2) and porcine circovirus type 3 (PCV3), significantly impact the global pig industry due to their high prevalence and pathogenicity. Conversely, porcine circovirus type 1 (PCV1) and porcine circovirus type 4 (PCV4) currently have low positivity rates. This study aimed to characterize the distribution and epidemiology of porcine circoviruses in Xinjiang, while also analyzing the genetic diversity and evolution of PCV2 and PCV3, which pose the greatest threats to the industry. In this study, we collected blood and tissue samples from 453 deceased pigs across eight regions in Xinjiang Province from 2022 to 2024. We utilized real-time PCR to detect the presence of PCV1, PCV2, PCV3, and PCV4. The positive rates were 15%, 71%, 25%, and 17%, respectively. Genetic analysis showed 9 PCV2 sequences and 12 PCV3 sequences. The capsid protein of PCV2 showed significant variability. In contrast, the amino acid sequences of capsid in PCV3 were relatively stable. Moreover, we predicted antigenic epitopes for PCV3 capsid using IEDB and ElliPro. The findings from this study provide valuable epidemiological data on PCV coinfection in the Xinjiang region and enhance the understanding of virus diversity nationwide. This research may serve as an important reference for the development of strategies to prevent and control porcine circovirus infections.

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新疆猪圆环病毒感染的流行病学调查与分析。

猪圆环病毒，尤其是猪圆环病毒 2 型 (PCV2) 和猪圆环病毒 3 型 (PCV3)，因其流行率高、致病性强而对全球养猪业产生了重大影响。相反，猪圆环病毒 1 型 (PCV1) 和猪圆环病毒 4 型 (PCV4) 目前的阳性率较低。本研究旨在描述新疆猪圆环病毒的分布和流行病学特征，同时分析对畜牧业威胁最大的 PCV2 和 PCV3 的遗传多样性和进化情况。在本研究中，我们采集了 2022 年至 2024 年新疆省 8 个地区 453 头死亡猪的血液和组织样本。我们利用实时 PCR 检测 PCV1、PCV2、PCV3 和 PCV4 的存在。阳性率分别为 15%、71%、25% 和 17%。基因分析显示有 9 个 PCV2 序列和 12 个 PCV3 序列。PCV2 的囊膜蛋白具有显著的变异性。相比之下，PCV3 的噬菌体氨基酸序列相对稳定。此外，我们还利用 IEDB 和 ElliPro 预测了 PCV3 荚膜的抗原表位。本研究结果为新疆地区 PCV 合并感染提供了宝贵的流行病学数据，并加深了对全国病毒多样性的了解。该研究可为制定猪圆环病毒感染防控策略提供重要参考。

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来源期刊

ACS Applied Energy Materials Materials Science-Materials Chemistry

CiteScore

10.30

自引率

6.20%

发文量

1368

期刊介绍： ACS Applied Energy Materials is an interdisciplinary journal publishing original research covering all aspects of materials, engineering, chemistry, physics and biology relevant to energy conversion and storage. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrate knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important energy applications.