Interplays Between Matrix Metalloproteinases and Neurotropic Viruses: An Overview.

IF 9 2区 医学 Q1 VIROLOGY
Suad A Alghamdi, Mohammed Alissa, Abdullah Alghamdi, Mohammed A Alshehri, Abdullah Albelasi, Khalid J Alzahrani, Awaji Y Safhi
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引用次数: 0

Abstract

Matrix metalloproteinases (MMPs) are a diverse group of proteases involved in various physiological and pathological processes through modulation of extracellular matrix (ECM) components, cytokines, and growth factors. In the central nervous system (CNS), MMPs play a major role in CNS development, plasticity, repair, and reorganisation contributing to learning, memory, and neuroimmune response to injury. MMPs are also linked to various neurological disorders such as Alzheimer's disease, Parkinson's disease, cerebral aneurysm, stroke, epilepsy, multiple sclerosis, and brain cancer suggesting these proteases as key regulatory factors in the nervous system. Moreover, MMPs have been involved in the pathogenesis of neurotropic viral infections via dysregulation of various cellular processes, which may highlight these factors as potential targets for the treatment and control of neurological complications associated with viral pathogens. This review provides an overview of the roles of MMPs in various physiological processes of the CNS and their interactions with neurotropic viral pathogens.

基质金属蛋白酶与神经病毒之间的相互作用:综述。
基质金属蛋白酶(MMPs)是一组多样化的蛋白酶,通过调节细胞外基质(ECM)成分、细胞因子和生长因子参与各种生理和病理过程。在中枢神经系统(CNS)中,MMPs 在中枢神经系统的发育、可塑性、修复和重组过程中发挥着重要作用,有助于学习、记忆和神经免疫损伤反应。MMPs 还与各种神经系统疾病有关,如阿尔茨海默病、帕金森病、脑动脉瘤、中风、癫痫、多发性硬化症和脑癌,这表明这些蛋白酶是神经系统的关键调节因子。此外,MMPs 还通过对各种细胞过程的失调参与了神经病毒感染的发病机制,这可能会使这些因子成为治疗和控制与病毒病原体相关的神经系统并发症的潜在靶点。本综述概述了 MMPs 在中枢神经系统各种生理过程中的作用及其与神经毒性病毒病原体的相互作用。
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来源期刊
Reviews in Medical Virology
Reviews in Medical Virology 医学-病毒学
CiteScore
21.40
自引率
0.90%
发文量
88
期刊介绍: Reviews in Medical Virology aims to provide articles reviewing conceptual or technological advances in diverse areas of virology. The journal covers topics such as molecular biology, cell biology, replication, pathogenesis, immunology, immunization, epidemiology, diagnosis, treatment of viruses of medical importance, and COVID-19 research. The journal has an Impact Factor of 6.989 for the year 2020. The readership of the journal includes clinicians, virologists, medical microbiologists, molecular biologists, infectious disease specialists, and immunologists. Reviews in Medical Virology is indexed and abstracted in databases such as CABI, Abstracts in Anthropology, ProQuest, Embase, MEDLINE/PubMed, ProQuest Central K-494, SCOPUS, and Web of Science et,al.
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