Olivia Agatha, Daniela Mutwil-Anderwald, Jhing Yein Tan, Marek Mutwil
{"title":"Plant sesquiterpene lactones.","authors":"Olivia Agatha, Daniela Mutwil-Anderwald, Jhing Yein Tan, Marek Mutwil","doi":"10.1098/rstb.2023.0350","DOIUrl":null,"url":null,"abstract":"<p><p>Sesquiterpene lactones (STLs) are a prominent group of plant secondary metabolites predominantly found in the Asteraceae family and have multiple ecological roles and medicinal applications. This review describes the evolutionary and ecological significance of STLs, highlighting their roles in plant defence mechanisms against herbivory and as phytotoxins, alongside their function as environmental signalling molecules. We also cover the substantial role of STLs in medicine and their mode of action in health and disease. We discuss the biosynthetic pathways and the various modifications that make STLs one of the most diverse groups of metabolites. Finally, we discuss methods for identifying and predicting STL biosynthesis pathways. This article is part of the theme issue 'The evolution of plant metabolism'.</p>","PeriodicalId":19872,"journal":{"name":"Philosophical Transactions of the Royal Society B: Biological Sciences","volume":"379 1914","pages":"20230350"},"PeriodicalIF":5.4000,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11449222/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Philosophical Transactions of the Royal Society B: Biological Sciences","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1098/rstb.2023.0350","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/9/30 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Sesquiterpene lactones (STLs) are a prominent group of plant secondary metabolites predominantly found in the Asteraceae family and have multiple ecological roles and medicinal applications. This review describes the evolutionary and ecological significance of STLs, highlighting their roles in plant defence mechanisms against herbivory and as phytotoxins, alongside their function as environmental signalling molecules. We also cover the substantial role of STLs in medicine and their mode of action in health and disease. We discuss the biosynthetic pathways and the various modifications that make STLs one of the most diverse groups of metabolites. Finally, we discuss methods for identifying and predicting STL biosynthesis pathways. This article is part of the theme issue 'The evolution of plant metabolism'.
期刊介绍：
The journal publishes topics across the life sciences. As long as the core subject lies within the biological sciences, some issues may also include content crossing into other areas such as the physical sciences, social sciences, biophysics, policy, economics etc. Issues generally sit within four broad areas (although many issues sit across these areas):
Organismal, environmental and evolutionary biology
Neuroscience and cognition
Cellular, molecular and developmental biology
Health and disease.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
