Posterior Vitreous Detachment and Risk of Neovascular Glaucoma in Eyes with Prior Retinal Vascular Occlusions.

IF 2.6 3区医学 Q2 OPHTHALMOLOGY

Ophthalmology and Therapy Pub Date : 2024-09-29 DOI:10.1007/s40123-024-01039-1

Laura D Palmer, Jared D Peterson, Joni K Evans, Mark H Nelson, Sanjay Asrani, Atalie C Thompson

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引用次数: 0

Abstract

Introduction: To investigate the impact of posterior vitreous detachment (PVD) on the risk of developing neovascular glaucoma (NVG) in eyes with occlusions of the retinal artery (RAO) or retinal vein (RVO).

Methods: Single-center retrospective case-control study of adults with a history of RVO/RAO. Cases (N = 101) who developed NVG were age and sex matched 1:2 to controls who did not develop NVG (N = 202). Multivariable logistic regression was used to estimate the association between history of PVD and risk of NVG while controlling for other related demographic or clinical factors.

Results: In initial bivariate analyses, there was no difference in risk of NVG based on eye, lens status, hypertension, history of panretinal photocoagulation (PRP), or retinal surgery (all p > 0.10), a borderline difference based on diabetic retinopathy (DR) (p = 0.06) and prior anti-vascular endothelial growth factor (anti-VEGF) treatment (p = 0.08), and a significant difference based on race/ethnicity, type of vascular event, and PVD status (all p < 0.05). In the final multivariable model, patients without PVD were significantly more likely to develop NVG (OR = 3.07, p = 0.0001) independent of the other covariates. Risk of NVG was greater in those with DR (OR = 1.98, p = 0.0440) and in those with central RVO vs. branch RVO/hemiretinal RVO (OR = 5.77, p < 0.0001). Non-White/Non-Hispanics (OR = 2.56, p = 0.0051) and Hispanics (OR = 3.65, p = 0.0288) were more likely than White patients to develop NVG.

Conclusions: Progression to NVG after retinal vascular occlusion is more likely in Non-White/Hispanic patients, those with concomitant DR, and those with CRVO/CRAO. The absence of PVD increases the risk for NVG. Further studies are necessary to understand this relationship.

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曾有视网膜血管闭塞的眼球后玻璃体脱离和新生血管性青光眼的风险。

简介研究玻璃体后脱离（PVD）对视网膜动脉（RAO）或视网膜静脉（RVO）闭塞患者罹患新生血管性青光眼（NVG）风险的影响：方法：对有 RVO/RAO 病史的成人进行单中心回顾性病例对照研究。出现 NVG 的病例（N = 101）与未出现 NVG 的对照组（N = 202）在年龄和性别上进行 1:2 匹配。在控制其他相关人口学或临床因素的前提下，采用多变量逻辑回归估算心血管病史与 NVG 风险之间的关系：在最初的双变量分析中，根据眼睛、晶状体状态、高血压、全视网膜光凝（PRP）或视网膜手术史，NVG 风险没有差异（所有 p > 0.10），根据糖尿病视网膜病变（DR）（p = 0.06）和之前的抗血管内皮生长因子（anti-VEGF）治疗（p = 0.08），以及种族/族裔、血管事件类型和 PVD 状态的显著差异（所有 p 均为 0.05）：非白种人/西班牙裔患者、同时患有 DR 和 CRVO/CRAO 的患者在视网膜血管闭塞后更有可能发展为 NVG。没有 PVD 会增加 NVG 的风险。要了解这种关系，还需要进一步的研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ophthalmology and Therapy OPHTHALMOLOGY-

CiteScore

4.20

自引率

3.00%

发文量

157

审稿时长

6 weeks

期刊介绍： Aims and Scope Ophthalmology and Therapy is an international, open access, peer-reviewed (single-blind), and rapid publication journal. The scope of the journal is broad and will consider all scientifically sound research from preclinical, clinical (all phases), observational, real-world, and health outcomes research around the use of ophthalmological therapies, devices, and surgical techniques. The journal is of interest to a broad audience of pharmaceutical and healthcare professionals and publishes original research, reviews, case reports/series, trial protocols and short communications such as commentaries and editorials. Ophthalmology and Therapy will consider all scientifically sound research be it positive, confirmatory or negative data. Submissions are welcomed whether they relate to an international and/or a country-specific audience, something that is crucially important when researchers are trying to target more specific patient populations. 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