Altered brain function in treatment-resistant depression patients: A resting-state functional magnetic resonance imaging study

IF 2.5 4区医学 Q3 NEUROSCIENCES

Neuroscience Letters Pub Date : 2024-09-26 DOI:10.1016/j.neulet.2024.138004

Weijian Han , Xiaohui Wu , Ligang Wang , Chunhui Qu , Liqiang Dou , Yiru Fang , Ping Sun

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引用次数: 0

Abstract

Background

It has been established that there are functional changes in the brain of treatment-resistant depression (TRD) patients, but previous studies of functional connectivity (FC) usually involved selection of regions of interest based on accumulated a priori knowledge of the disorder. In this study, we combine amplitude of low-frequency fluctuation (ALFF) and FC; this approach, based on the abnormal ALFF, may provide some insights into the neural basis of the disease in terms of fMRI signals of low-frequency fluctuations.

Methods

A total of 16 TRD patients, who visited the Qingdao Mental Health Center, Shandong Province, China between March 2023 and January 2024, along with 16 normal subjects, were enrolled into this study for functional imaging. In this study, we first explored the ALFF changes of TRD patients at a baseline resting state. Second, we selected the regions that were significantly changed in the ALFF as seeds and calculated the regional activity and functional connectivity (FC) of these regions using a seed-based approach. We also calculated correlations between the percent change in the PDQ-5D scores and ALFF values in brain regions with differing activity for TRD patients.

Results

During the baseline resting state, by using the ALFF, we found a significantly decreased or increased ALFF in the TRD patients relative to the controls. These regions were located in the left/right postcentral gyrus (PoCG.L/PoCG.R), right cuneus(CUN.R). We found that the ALFF values of the right hippocampus (HIP.R) in the TRD group were negatively correlated with the PDQ-5D score. Then, we selected these brain regions as seeds to investigate the FC changes in brains of TRD patients. We found abnormal functional connectivity in left/right middle frontal gyrus(MFG.L/MFG.R), the right Inferior frontal gyrus, opercular part (IFGoperc.R), the left/right Anterior cingulate and paracingulate gyri (ACC.L/ACC.R), the right supramarginal gyrus (SMG.R), and the right Calcarine fissure and surrounding cortex (CAL.R).

Conclusion

We found a larger range of altered brain regions in TRD patients compared to healthy controls, especially in the central executive network (CEN), salience network (SN) and default mode network (DMN).

查看原文本刊更多论文

耐药抑郁症患者大脑功能的改变：静息态功能磁共振成像研究。

背景：耐药抑郁症（TRD）患者的大脑存在功能性变化已被证实，但以往的功能连通性（FC）研究通常是根据对该疾病积累的先验知识来选择感兴趣的区域。在本研究中，我们将低频波动振幅（ALFF）和FC结合在一起；这种基于低频波动振幅异常的方法可能会从低频波动的fMRI信号方面为该疾病的神经基础提供一些见解：方法：本研究共纳入了 16 名于 2023 年 3 月至 2024 年 1 月在山东省青岛市精神卫生中心就诊的 TRD 患者和 16 名正常人，对其进行功能成像。在这项研究中，我们首先探讨了TRD患者在基线静息状态下的ALFF变化。其次，我们选择了在 ALFF 中发生显著变化的区域作为种子，并采用基于种子的方法计算了这些区域的区域活动和功能连接（FC）。我们还计算了TRD患者PDQ-5D评分变化百分比与脑区不同活动度的ALFF值之间的相关性：结果：通过使用 ALFF，我们发现在基线静息状态下，TRD 患者的 ALFF 相对于对照组显著降低或升高。这些区域位于左/右中央后回（PoCG.L/PoCG.R）、右楔（CUN.R）。我们发现，TRD组右侧海马（HIP.R）的ALFF值与PDQ-5D评分呈负相关。于是，我们选择这些脑区作为种子，研究TRD患者大脑的功能连接变化。我们发现左/右额叶中回（MFG.L/MFG.R）、右额叶下回厣部（IFGoperc.R）、左/右扣带回前部和旁扣带回（ACC.L/ACC.R）、右侧边际上回（SMG.R）和右侧钙化裂及其周围皮层（CAL.R）的功能连接异常：结论：与健康对照组相比，我们发现TRD患者脑区发生改变的范围更大，尤其是在中央执行网络（CEN）、显著性网络（SN）和默认模式网络（DMN）中。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neuroscience Letters 医学-神经科学

CiteScore

5.20

自引率

0.00%

发文量

408

审稿时长

50 days

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