Effect of deep brain stimulation on sexual dysfunction among patients who had Parkinson's disease: a systematic review and meta-analysis.

IF 1.7 4区医学 Q3 CLINICAL NEUROLOGY

Neurological Research Pub Date : 2024-12-01 Epub Date: 2024-10-01 DOI:10.1080/01616412.2024.2407645

Amir Reza Bahadori, Rasa Zafari, Mohammad Amin Fathollahi, Afshan Davari, Mehrdad Sheikhvatan, Sara Ranji, Abbas Tafakhori

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引用次数: 0

Abstract

Background: Patients who have Parkinson's disease (PD) present several non-motor issues, such as sexual dysfunction. Deep brain stimulation (DBS) is a great treatment for PD and could affect both motor and non-motor symptoms of patients.

Aim: The main goal of the current study is to evaluate the impact of DBS on the sexual dysfunction among patients with PD.

Methods: Five databases (PubMed, Scopus, Embase, Web of Science, and Cochrane Library) were searched for records. Studies that measured the effect of DBS sexual function were included. The risk of bias assessment tool of non-randomized studies of interventions (ROBINS-I) was used to assess the quality of the included studies. The before and after data extraction and statistical analysis were performed using the Comprehensive Meta-analysis software (CMA) version 3.0.

Result: Ten studies were included in the systematic review; six of them were eligible to perform a meta-analysis with a total sample size of 532 participants and a mean age of 62.21 ± 1.59 years. All participants performed STN-DBS. The sexual function of participants after STN-DBS implantation significantly increased (SMD = -0.124, 95% CI: -0.209 to -0.038, P-value = 0.005). It also did not have any publication bias. Additionally, their quality of life mounts significantly (SMD = -0.712, 95% CI: -1.002 to -0.422, p-value <0.001).

Conclusion: Our systematic review highlights the potential effect of STN-DBS on reducing the sexual dysfunction of patients with PD and boosting their quality of life.

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脑深部刺激对帕金森病患者性功能障碍的影响：系统回顾和荟萃分析。

背景：帕金森病（PD）患者会出现一些非运动问题，如性功能障碍。目的：本研究的主要目的是评估深部脑刺激（DBS）对帕金森病患者性功能障碍的影响：方法：检索五个数据库（PubMed、Scopus、Embase、Web of Science 和 Cochrane Library）中的记录。纳入了测量 DBS 性功能影响的研究。采用非随机干预研究偏倚风险评估工具（ROBINS-I）评估纳入研究的质量。前后数据提取和统计分析使用综合元分析软件（CMA）3.0.版本进行：系统综述共纳入 10 项研究，其中 6 项符合进行荟萃分析的条件，总样本量为 532 人，平均年龄为 62.21 ± 1.59 岁。所有参与者均接受了 STN-DBS。植入 STN-DBS 后，参与者的性功能显著增强（SMD = -0.124，95% CI：-0.209 至 -0.038，P 值 = 0.005）。该研究也没有任何发表偏倚。此外，他们的生活质量也明显下降（SMD = -0.712，95% CI：-1.002 至 -0.422，P 值结论：我们的系统综述强调了 STN-DBS 对减少帕金森病患者性功能障碍和提高其生活质量的潜在作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neurological Research 医学-临床神经学

CiteScore

3.60

自引率

0.00%

发文量

116

审稿时长

5.3 months

期刊介绍： Neurological Research is an international, peer-reviewed journal for reporting both basic and clinical research in the fields of neurosurgery, neurology, neuroengineering and neurosciences. It provides a medium for those who recognize the wider implications of their work and who wish to be informed of the relevant experience of others in related and more distant fields. The scope of the journal includes: •Stem cell applications •Molecular neuroscience •Neuropharmacology •Neuroradiology •Neurochemistry •Biomathematical models •Endovascular neurosurgery •Innovation in neurosurgery.