Uveitis: A snapshot in the MOG antibody spectrum.

IF 4.8 2区 医学 Q1 CLINICAL NEUROLOGY
Claudia Fabiani, Gian Marco Tosi, Valentina Damato, Monica Ulivelli, Alessandra Rufa, Alfonso Cerase, Nicola De Stefano, Rosa Cortese
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引用次数: 0

Abstract

Despite the commonly observed association of anti-myelin oligodendrocyte glycoprotein (MOG) antibodies with bilateral optic neuritis, their connection to uveitis is largely unexplored. The presented case involves a 41-year-old male with uveitis and bilateral optic neuritis, subsequently diagnosed with myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD). This case, characterized by bilateral optic neuritis associated to anti-MOG antibodies and the concurrent onset of unilateral anterior uveitis, provides further evidence concerning the features of intraocular inflammation in MOGAD. The patient's treatment response, including the use of rituximab due to contraindications to oral steroids, emphasizes the importance of personalized management strategies in MOGAD-associated ocular manifestations.

葡萄膜炎MOG 抗体谱的一个缩影。
尽管抗髓鞘少突胶质细胞糖蛋白(MOG)抗体通常与双侧视神经炎有关,但它们与葡萄膜炎的关系在很大程度上还未被研究。本病例涉及一名患有葡萄膜炎和双侧视神经炎的41岁男性,随后被诊断为髓鞘少突胶质细胞糖蛋白抗体相关疾病(MOGAD)。该病例的特点是双侧视神经炎与抗 MOG 抗体相关,并同时出现单侧前葡萄膜炎,这为 MOGAD 眼内炎症的特征提供了进一步的证据。该患者的治疗反应,包括因口服类固醇禁忌症而使用利妥昔单抗,强调了个性化治疗策略在MOGAD相关眼部表现中的重要性。
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来源期刊
Multiple Sclerosis Journal
Multiple Sclerosis Journal 医学-临床神经学
CiteScore
10.90
自引率
6.90%
发文量
186
审稿时长
3-8 weeks
期刊介绍: Multiple Sclerosis Journal is a peer-reviewed international journal that focuses on all aspects of multiple sclerosis, neuromyelitis optica and other related autoimmune diseases of the central nervous system. The journal for your research in the following areas: * __Biologic basis:__ pathology, myelin biology, pathophysiology of the blood/brain barrier, axo-glial pathobiology, remyelination, virology and microbiome, immunology, proteomics * __Epidemology and genetics:__ genetics epigenetics, epidemiology * __Clinical and Neuroimaging:__ clinical neurology, biomarkers, neuroimaging and clinical outcome measures * __Therapeutics and rehabilitation:__ therapeutics, rehabilitation, psychology, neuroplasticity, neuroprotection, and systematic management Print ISSN: 1352-4585
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