Chronic cannabidiol treatment induces cardiovascular improvement in renovascular hypertensive rats.

IF 4.3 3区材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC

ACS Applied Electronic Materials Pub Date : 2024-09-30 DOI:10.1097/HJH.0000000000003865

Atalia Ferreira Lima Flôr, Samuel Duarte-Maia, Francineide Fernandes-Costa, Rayane Maria Pessoa de Souza, Valdir de Andrade Braga, Sandra Lia do Amaral, Sandra Rodrigues Mascarenhas, José Luiz Brito-Alves, Debora Simões Almeida Colombari, Josiane Campos Cruz

{"title":"Chronic cannabidiol treatment induces cardiovascular improvement in renovascular hypertensive rats.","authors":"Atalia Ferreira Lima Flôr, Samuel Duarte-Maia, Francineide Fernandes-Costa, Rayane Maria Pessoa de Souza, Valdir de Andrade Braga, Sandra Lia do Amaral, Sandra Rodrigues Mascarenhas, José Luiz Brito-Alves, Debora Simões Almeida Colombari, Josiane Campos Cruz","doi":"10.1097/HJH.0000000000003865","DOIUrl":null,"url":null,"abstract":"Background: Cannabidiol (CBD) is increasingly studied for its therapeutic potential in neurodegenerative diseases. Previous research on acute CBD administration has demonstrated cardiovascular benefits in hypertensive rats, including reduced mean blood pressure and oxidative stress.Aim: To investigate the long-term cardiovascular effects of chronic CBD treatment in renovascular hypertension induced by the 2-kidney-1-clip (2K1C) model.Methods: Male Wistar rats (180-200 g, 8 weeks old) underwent 2K1C or SHAM surgery. Six weeks later, rats received chronic CBD treatment (20 mg/kg, twice daily for 14 days). A combination of ex vivo, in vitro, and in vivo methods was used to assess CBD's cardiovascular effects in 2K1C hypertensive rats.Results: Chronic CBD treatment significantly reduced blood pressure and the depressor response to hexamethonium (a ganglionic blocker). It also normalized variability in low-frequency (LF) power and LF/high-frequency (HF) ratio. CBD enhanced vasodilation and reduced vasoconstriction in the mesenteric artery of 2K1C rats, accompanied by decreased expression of aortic reactive oxygen species (ROS).Conclusion: Our findings suggest that chronic CBD treatment exerts antihypertensive effects by improving baroreflex sensitivity and vascular function while decreasing arterial ROS levels and sympathetic nerve activity. These results underscore CBD's potential therapeutic role in managing cardiovascular complications associated with renovascular hypertension.","PeriodicalId":3,"journal":{"name":"ACS Applied Electronic Materials","volume":null,"pages":null},"PeriodicalIF":4.3000,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Applied Electronic Materials","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1097/HJH.0000000000003865","RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENGINEERING, ELECTRICAL & ELECTRONIC","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Cannabidiol (CBD) is increasingly studied for its therapeutic potential in neurodegenerative diseases. Previous research on acute CBD administration has demonstrated cardiovascular benefits in hypertensive rats, including reduced mean blood pressure and oxidative stress.

Aim: To investigate the long-term cardiovascular effects of chronic CBD treatment in renovascular hypertension induced by the 2-kidney-1-clip (2K1C) model.

Methods: Male Wistar rats (180-200 g, 8 weeks old) underwent 2K1C or SHAM surgery. Six weeks later, rats received chronic CBD treatment (20 mg/kg, twice daily for 14 days). A combination of ex vivo, in vitro, and in vivo methods was used to assess CBD's cardiovascular effects in 2K1C hypertensive rats.

Results: Chronic CBD treatment significantly reduced blood pressure and the depressor response to hexamethonium (a ganglionic blocker). It also normalized variability in low-frequency (LF) power and LF/high-frequency (HF) ratio. CBD enhanced vasodilation and reduced vasoconstriction in the mesenteric artery of 2K1C rats, accompanied by decreased expression of aortic reactive oxygen species (ROS).

Conclusion: Our findings suggest that chronic CBD treatment exerts antihypertensive effects by improving baroreflex sensitivity and vascular function while decreasing arterial ROS levels and sympathetic nerve activity. These results underscore CBD's potential therapeutic role in managing cardiovascular complications associated with renovascular hypertension.

查看原文本刊更多论文

慢性大麻二酚治疗可诱导翻新血管性高血压大鼠的心血管状况得到改善。

背景：人们越来越多地研究大麻二酚（CBD）对神经退行性疾病的治疗潜力。目的：研究慢性 CBD 治疗对 2 肾 1 夹（2K1C）模型诱导的新血管性高血压的长期心血管影响：雄性 Wistar 大鼠（180-200 克，8 周龄）接受 2K1C 或 SHAM 手术。六周后，大鼠接受慢性 CBD 治疗（20 毫克/千克，每天两次，共 14 天）。我们采用了体外、体外和体内相结合的方法来评估 CBD 对 2K1C 高血压大鼠心血管的影响：结果：长期服用 CBD 能明显降低血压和对六甲蜜胺（一种神经节阻滞剂）的抑制反应。它还能使低频（LF）功率和低频/高频（HF）比率的变化正常化。CBD 增强了 2K1C 大鼠肠系膜动脉的血管舒张，减少了血管收缩，同时降低了主动脉活性氧（ROS）的表达：我们的研究结果表明，长期服用 CBD 可改善气压反射敏感性和血管功能，同时降低动脉 ROS 水平和交感神经活性，从而发挥降压作用。这些结果凸显了 CBD 在控制新血管性高血压相关心血管并发症方面的潜在治疗作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

ACS Applied Electronic Materials Multiple-

CiteScore

7.20

自引率

4.30%

发文量

567