Impact of high-protein enteral nutrition on muscle preservation in mechanically ventilated patients with severe pneumonia: a randomized controlled trial.

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS
Cheng Liu, Li He, Jin Hui Zhang, JiangShan He, Lin Tian, Xiangde Zheng
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引用次数: 0

Abstract

Background: This study aimed to assess the effects of enteral nutrition with different protein concentrations on muscle mass in severe pneumonia patients, providing insights for enteral nutrition practice in intensive care units (ICUs).

Methods: A total of 120 severe pneumonia patients admitted to Dazhou Central Hospital's ICU between June 1, 2022, and February 1, 2023, meeting inclusion criteria, were randomly assigned to either a high-protein group (n = 60, 1.8 g/kg/d) or a standard-protein group (n = 60, 1.2 g/kg/d). Changes in relevant indicators were monitored on days 1, 5, and 10 of ICU admission, including quadriceps and diaphragm thickness, nutritional status (prealbumin and albumin), and adverse events such as diarrhea and constipation.

Results: Autoregressive of order 1 model (AR(1)) analysis revealed a decrease in both quadriceps and diaphragm thickness over time in both groups. A significant group × time interaction was observed in quadriceps thickness. By day 10, compared to baseline, quadriceps thickness decreased in the high-protein (-0.315 cm [95% CI, -0.340 to -0.289]) and standard-protein (-0.429 cm [95% CI, -0.455 to -0.404]) groups. The high-protein group exhibited a lower quadriceps atrophy rate (13.97 ± 2.43%) compared to the standard-protein group (18.96 ± 2.61%), showing a significant difference (P < 0.001). No significant differences were found in diaphragmatic thickness between groups and over time. By day 10, both groups exhibited decreased diaphragmatic muscle thickness compared to baseline. The high-protein group (33.76 ± 5.09%) had a slightly lower phrenic atrophy rate compared to the standard-protein group (33.41 ± 4.53%). Both groups experienced enteral nutritional intolerance manifested as diarrhea, constipation, and other adverse events.

Conclusion: High-protein enteral nutrition significantly improved quadriceps thickness and demonstrated good safety in severe pneumonia patients, suggesting its suitability for widespread clinical application.

高蛋白肠内营养对重症肺炎机械通气患者肌肉保存的影响:随机对照试验。
背景:本研究旨在评估不同蛋白质浓度的肠内营养对重症肺炎患者肌肉质量的影响:本研究旨在评估不同蛋白质浓度的肠内营养对重症肺炎患者肌肉质量的影响,为重症监护病房(ICU)的肠内营养实践提供启示:2022年6月1日至2023年2月1日期间,达州市中心医院重症监护室共收治了120名符合纳入标准的重症肺炎患者,他们被随机分配到高蛋白组(n = 60,1.8 g/kg/d)或标准蛋白组(n = 60,1.2 g/kg/d)。在入住重症监护室的第1天、第5天和第10天监测相关指标的变化,包括股四头肌和膈肌厚度、营养状况(前白蛋白和白蛋白)以及腹泻和便秘等不良事件:1阶自回归模型(AR(1))分析显示,随着时间的推移,两组患者的股四头肌和膈肌厚度均有所下降。在股四头肌厚度方面,观察到了明显的组×时间交互作用。到第 10 天,与基线相比,高蛋白组(-0.315 厘米 [95% CI,-0.340 至 -0.289])和标准蛋白组(-0.429 厘米 [95% CI,-0.455 至 -0.404])的股四头肌厚度均有所下降。与标准蛋白质组(18.96 ± 2.61%)相比,高蛋白组的股四头肌萎缩率(13.97 ± 2.43%)较低,差异显著(P 结论:高蛋白肠内营养显著改善了患者的股四头肌萎缩率:高蛋白肠内营养能明显改善重症肺炎患者的股四头肌厚度,并表现出良好的安全性,表明其适合广泛应用于临床。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
ACS Applied Bio Materials
ACS Applied Bio Materials Chemistry-Chemistry (all)
CiteScore
9.40
自引率
2.10%
发文量
464
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