Three new cyclopentanoid monoterpenes from the roots of Picrorhiza scrophulariiflora.

IF 1.3 3区医学 Q3 CHEMISTRY, APPLIED

Journal of Asian Natural Products Research Pub Date : 2024-09-27 DOI:10.1080/10286020.2024.2408547

Xin-Yue Li, Jie Zhou, Guo-Ru Shi, Wan-Qi Zhang, Ming-Hui Sun, Jing-Han Zhang, Xin-Li Ma, Gu Zhao, Yan-Fei Liu, De-Quan Yu

引用次数: 0

Abstract

Three new cyclopentanoid monoterpenes, neopiscrocins A-C (1-3), together with 14 known compounds (4-17), were isolated from the roots of Picrorhiza scrophulariiflora. The structres of these compounds were elucidated on the basis of their spectroscopic data. All compounds were evaluated for cytotoxicity against six human tumor cell lines (PC9, PANC1, HCT-116, Hep-G2, BGC-823, and MCF-7), hepatoprotective activity and anti-inflammatory activity.

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来自 Picrorhiza scrophulariiflora 根部的三种新的环戊烷单萜烯。

从 Picrorhiza scrophulariiflora 的根中分离出了三种新的环戊烷单萜烯类化合物，即 neopiscrocins A-C (1-3)，以及 14 种已知化合物 (4-17)。这些化合物的结构是根据其光谱数据阐明的。评估了所有化合物对六种人类肿瘤细胞系（PC9、PANC1、HCT-116、Hep-G2、BGC-823 和 MCF-7）的细胞毒性、保肝活性和抗炎活性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.