Transfer RNAs and transfer RNA-derived small RNAs in cerebrovascular diseases

IF 4.6 2区医学 Q1 NEUROSCIENCES

Experimental Neurology Pub Date : 2024-09-24 DOI:10.1016/j.expneurol.2024.114971

Jiajie Yuan , Zibin Song , Jun Liu , Khalil Ur Rahman , Qixiong Zhou , Guangjie Liu , Yifeng Deng , Haotian Wen , Xiaonan Fan , Nanqi Fang , Zhaojun Zhou , Qiancheng Song , Guozhong Zhang , Peng Li , Ye Song

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引用次数: 0

Abstract

This article explores the important functions of transfer RNA and - transfer RNA derived small RNAs (tsRNAs) in cellular processes and disease pathogenesis, with a particular emphasis on their involvement in cerebrovascular disorders. It discusses the biogenesis and structure of tsRNAs, including types such as tRNA halves and tRNA-derived fragments, and their functional significance in gene regulation, stress response, and cell signaling pathways. The importance of tsRNAs in neurodegenerative diseases, cancer, and cardiovascular diseases has already been highlighted, while their role in cerebrovascular diseases is in early phase of exploration. This paper presents the latest advancements in the field of tsRNAs in cerebrovascular conditions, such as ischemic stroke, intracerebral hemorrhage, and moyamoya disease. Furthermore, revealing the aptitude of tsRNAs as biomarkers for the prediction of cerebrovascular diseases and as targets for therapeutic intervention. It provides insights into the role of tsRNAs in these conditions and proposes directions for future research.

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脑血管疾病中的转运核糖核酸和转运核糖核酸衍生小核糖核酸。

本文探讨了转运核糖核酸和转运核糖核酸衍生的小核糖核酸（tsRNA）在细胞过程和疾病发病机制中的重要功能，特别强调了它们在脑血管疾病中的参与。该书讨论了 tsRNA 的生物发生和结构，包括 tRNA 半体和 tRNA 衍生片段等类型，以及它们在基因调控、应激反应和细胞信号通路中的功能意义。tsRNA在神经退行性疾病、癌症和心血管疾病中的重要性已经得到强调，而它们在脑血管疾病中的作用还处于早期探索阶段。本文介绍了 tsRNAs 在缺血性中风、脑内出血和 moyamoya 病等脑血管疾病中的最新研究进展。此外，还揭示了 tsRNA 作为预测脑血管疾病的生物标志物和治疗干预靶点的能力。该研究深入探讨了 tsRNAs 在这些疾病中的作用，并提出了未来的研究方向。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Experimental Neurology 医学-神经科学

CiteScore

10.10

自引率

3.80%

发文量

258

审稿时长

42 days

期刊介绍： Experimental Neurology, a Journal of Neuroscience Research, publishes original research in neuroscience with a particular emphasis on novel findings in neural development, regeneration, plasticity and transplantation. The journal has focused on research concerning basic mechanisms underlying neurological disorders.