Chemical composition and antifungal efficacy of Tunisian Prunus armeniaca L. kernels with formulation of an antidermatophyte cream based on kernel powder

IF 2.5 3区医学 Q3 CHEMISTRY, MEDICINAL

Fitoterapia Pub Date : 2024-09-26 DOI:10.1016/j.fitote.2024.106223

Soukaina Hrichi , Raja Chaâbane-Banaoues , Haikel Hrichi , Sameh Belgacem , Oussama Babba , Guido Flamini , Hamouda Babba

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引用次数: 0

Abstract

The biological activities of plant products are extremely correlated to the constituents present in each derivate. The present research aims to obtain by gas chromatography, the chemical profile of Prunus armeniaca L. kernel volatile fractions. The evaluation of the in vitro antifungal activities of the sterilized powder and volatile fractions of the plant P. armeniaca L. kernels was performed. Diffusion in a solid medium and broth microdilution methods were applied on fungi with medical importance (dermatophytes, yeasts and Aspergillus spp.). P. armeniaca L. powder based antidermatphyte cream has been formulated. Hydro-distillation generated two volatile fractions (VF1 and VF2) and chromatographic analysis showed the presence of three compounds for VF1 (98.7 % benzaldehyde, 1.0 % benzyl alcohol and 0.3 % 1,8-cineole) and two compounds for VF2 (90.3 % benzaldehyde and 9.3 % benzyl alcohol). The 2.5 % to 5 % concentrations in powder showed antifungal activities against dermatophytic strains. 1.25 to 2 mg/mL concentrations in volatile fractions were efficient against yeast strains, with a better efficiency for the VF1. The creams formulated were stable, cosmetically attractive with satisfactory pH, viscosity and spread ability. Prunus armeniaca L. kernel powders and the cream derived from them exhibit potent antifungal activities. This work presents a simple, ecological and economical means of formulating antifungal active substances and valorizing natural products.

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以核仁粉末为基础配制的抗皮肤癣菌霜中的突尼斯杨梅核仁的化学成分和抗真菌功效。

植物产品的生物活性与每种衍生物中的成分密切相关。本研究旨在通过气相色谱法获得杏核挥发性馏分的化学特征。研究人员还对杏仁的灭菌粉末和挥发性馏分的体外抗真菌活性进行了评估。对具有重要医学价值的真菌（皮癣菌、酵母菌和曲霉菌属）采用了固体培养基扩散法和肉汤微量稀释法。已配制出基于 P. armeniaca L. 粉末的抗皮肤病霜。水蒸馏产生了两种挥发性馏分（VF1 和 VF2），色谱分析显示 VF1 含有三种化合物（98.7 % 苯甲醛、1.0 % 苯甲醇和 0.3 % 1,8-蒎烯），VF2 含有两种化合物（90.3 % 苯甲醛和 9.3 % 苯甲醇）。粉末中 2.5 % 至 5 % 的浓度显示了对皮癣菌株的抗真菌活性。挥发性馏分中 1.25 至 2 毫克/毫升的浓度对酵母菌株有效，其中 VF1 的效率更高。配制的膏霜稳定、美观，具有令人满意的 pH 值、粘度和涂抹能力。杏核粉及其制成的膏霜具有很强的抗真菌活性。这项研究提出了一种简单、生态和经济的方法来配制抗真菌活性物质，实现天然产品的价值化。

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来源期刊

Fitoterapia 医学-药学

CiteScore

5.80

自引率

2.90%

发文量

198

审稿时长

1.5 months

期刊介绍： Fitoterapia is a Journal dedicated to medicinal plants and to bioactive natural products of plant origin. It publishes original contributions in seven major areas: 1. Characterization of active ingredients of medicinal plants 2. Development of standardization method for bioactive plant extracts and natural products 3. Identification of bioactivity in plant extracts 4. Identification of targets and mechanism of activity of plant extracts 5. Production and genomic characterization of medicinal plants biomass 6. Chemistry and biochemistry of bioactive natural products of plant origin 7. Critical reviews of the historical, clinical and legal status of medicinal plants, and accounts on topical issues.