Exploring the Therapeutic Potential of Glycyrrhiza Compounds in Alzheimer's Disease: A Comprehensive Review.

IF 2.9 4区医学 Q3 CHEMISTRY, MEDICINAL

Current topics in medicinal chemistry Pub Date : 2024-09-25 DOI:10.2174/0115680266322320240911194626

Xiaona Song, Xiaotang Wang, Yao Gao, Guoqiang Xu, Xiaoru Yan, Zhaoyang Chen, Guohua Song

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引用次数: 0

Abstract

Alzheimer's disease (AD) is a progressive neurodegenerative disorder. Research shows that the development of AD is linked to neuroinflammation, endoplasmic reticulum stress, mitochondrial dysfunction, cell death, and abnormal cholinergic signaling. Glycyrrhiza compounds contain active ingredients and extracts that offer multiple benefits, including targeting various pathways, high efficacy with low toxicity, and long-lasting therapeutic effects. These benefits highlight the significant potential of Glycyrrhiza compounds for preventing and treating AD. This review summarizes recent advancements in Glycyrrhiza compounds for preventing and treating AD. It focuses on their inhibitory effects on key signaling pathways, such as Toll-like receptor 4 (TLR4), nuclear factor-κB (NF-κB), mitogen-activated protein kinase (MAPK), and cholinergic signaling. This study aims to establish a scientific framework for using Glycyrrhiza compounds in the clinical prevention and treatment of AD and to support the development of new therapeutic interventions.

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探索甘草化合物对阿尔茨海默病的治疗潜力：全面综述。

阿尔茨海默病（AD）是一种进行性神经退行性疾病。研究表明，阿尔茨海默病的发生与神经炎症、内质网应激、线粒体功能障碍、细胞死亡和胆碱能信号异常有关。甘草化合物所含的活性成分和提取物具有多种益处，包括针对各种途径、高效低毒、疗效持久等。这些优点凸显了甘草化合物在预防和治疗注意力缺失症方面的巨大潜力。这篇综述总结了甘草化合物在预防和治疗注意力缺失症方面的最新进展。其重点是甘草化合物对关键信号通路的抑制作用，如Toll样受体4（TLR4）、核因子κB（NF-κB）、丝裂原活化蛋白激酶（MAPK）和胆碱能信号传导。这项研究旨在建立一个科学框架，将甘草化合物用于临床预防和治疗注意力缺失症，并支持开发新的治疗干预措施。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current topics in medicinal chemistry 医学-医药化学

CiteScore

6.40

自引率

2.90%

发文量

186

审稿时长

3-8 weeks

期刊介绍： Current Topics in Medicinal Chemistry is a forum for the review of areas of keen and topical interest to medicinal chemists and others in the allied disciplines. Each issue is solely devoted to a specific topic, containing six to nine reviews, which provide the reader a comprehensive survey of that area. A Guest Editor who is an expert in the topic under review, will assemble each issue. The scope of Current Topics in Medicinal Chemistry will cover all areas of medicinal chemistry, including current developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, compound diversity measurements, drug absorption, drug distribution, metabolism, new and emerging drug targets, natural products, pharmacogenomics, and structure-activity relationships. Medicinal chemistry is a rapidly maturing discipline. The study of how structure and function are related is absolutely essential to understanding the molecular basis of life. Current Topics in Medicinal Chemistry aims to contribute to the growth of scientific knowledge and insight, and facilitate the discovery and development of new therapeutic agents to treat debilitating human disorders. The journal is essential for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important advances.