An Overview of Research Advances in Oncology Regarding the Transcription Factor ATF4.

IF 3 4区医学 Q2 PHARMACOLOGY & PHARMACY

Current drug targets Pub Date : 2024-09-30 DOI:10.2174/0113894501328461240921062056

Yulu Chen, Qi Gao, Dan Wang, Xun Zou, Xiuming Li, Jing Ji, Bin Liu

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Abstract

This review provides a comprehensive overview of the recent advancements in research on ATF4 (Activating Transcription Factor 4) within the field of oncology. As a crucial transcription factor, ATF4 has garnered increasing attention for its role in cancer research. The review begins with an exploration of the regulatory mechanisms of ATF4, including its transcriptional control, post-translational modifications, and interactions with other transcription factors. It then highlights key research findings on ATF4's involvement in various aspects of tumor biology, such as cell proliferation, differentiation, apoptosis and survival, invasion and metastasis, and the tumor microenvironment. Furthermore, the review discusses the potential of targeting ATF4 as a novel therapeutic strategy for cancer treatment. It also explores how ATF4's interactions with existing anticancer drugs could inform the development of more effective therapeutic agents. By elucidating the role of ATF4 in tumor biology and its potential clinical applications, this review aims to provide new insights and strategies for cancer treatment.

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有关转录因子 ATF4 的肿瘤学研究进展综述。

本综述全面概述了肿瘤学领域有关 ATF4（激活转录因子 4）研究的最新进展。作为一种重要的转录因子，ATF4 在癌症研究中的作用日益受到关注。综述首先探讨了 ATF4 的调控机制，包括其转录控制、翻译后修饰以及与其他转录因子的相互作用。然后重点介绍了 ATF4 参与肿瘤生物学各方面（如细胞增殖、分化、凋亡和存活、侵袭和转移以及肿瘤微环境）的主要研究成果。此外，综述还讨论了靶向 ATF4 作为一种新型癌症治疗策略的潜力。它还探讨了 ATF4 与现有抗癌药物的相互作用如何为开发更有效的治疗药物提供信息。通过阐明 ATF4 在肿瘤生物学中的作用及其潜在的临床应用，本综述旨在为癌症治疗提供新的见解和策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current drug targets 医学-药学

CiteScore

6.20

自引率

0.00%

发文量

127

审稿时长

3-8 weeks

期刊介绍： Current Drug Targets aims to cover the latest and most outstanding developments on the medicinal chemistry and pharmacology of molecular drug targets e.g. disease specific proteins, receptors, enzymes, genes. Current Drug Targets publishes guest edited thematic issues written by leaders in the field covering a range of current topics of drug targets. The journal also accepts for publication mini- & full-length review articles and drug clinical trial studies. As the discovery, identification, characterization and validation of novel human drug targets for drug discovery continues to grow; this journal is essential reading for all pharmaceutical scientists involved in drug discovery and development.