What About the Others? Clinical Management of Gynecologic Cancer Risk in Patients With Moderate-Risk Hereditary Cancer Genes ( ATM , BRIP1 , RAD51C , RAD51D , and PALB2 ).

IF 1.4 4区医学 Q3 OBSTETRICS & GYNECOLOGY

Clinical obstetrics and gynecology Pub Date : 2024-12-01 Epub Date: 2024-09-26 DOI:10.1097/GRF.0000000000000897

Ester I Goldfeld, Brianna E Kelly, Kari L Ring

引用次数: 0

Abstract

Hereditary cancer syndromes associated with gynecologic malignancies account for up to 18% of all cases of ovarian, uterine, and cervical cancers, and identification of these syndromes has implications for cancer screening and risk reduction techniques in affected patients. The associated cancer risks with moderate-penetrance genes are rapidly evolving and present variable risks for the provider counseling the patient. In this review, we detail the cancer risk and management of patients with germline PV in the moderate-risk hereditary cancer genes ATM , BRIP1 , RAD51C , RAD51D , and PALB2 .

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其他基因如何？中度风险遗传性癌症基因（ATM、BRIP1、RAD51C、RAD51D 和 PALB2）患者的妇科癌症风险临床管理。

与妇科恶性肿瘤相关的遗传性癌症综合征占所有卵巢癌、子宫癌和宫颈癌病例的 18%。与中度遗传风险基因相关的癌症风险正在迅速演变，给提供咨询的医生和患者带来了不同的风险。在这篇综述中，我们将详细介绍中度风险遗传性癌症基因 ATM、BRIP1、RAD51C、RAD51D 和 PALB2 的癌症风险和种系 PV 患者的管理。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical obstetrics and gynecology 医学-妇产科学

CiteScore

2.70

自引率

0.00%

发文量

186

审稿时长

3 months

期刊介绍： Each issue of Clinical Obstetrics and Gynecology is a complete symposium on one or two timely topics of interest in obstetrics and gynecology. For each quarterly issue, two prominent guest editors solicit contributions on key clinical topics of interest to practicing physicians. Procedures, current clinical problems, medical and surgical treatments, and effective diagnostic aids are all carefully reviewed in original articles. The result is an instructive resource that dispenses trustworthy clinical guidance that enhances your understanding of key areas of your practice.