Metabolic dysfunction-associated steatotic liver disease and cardiovascular risk: a comprehensive review.

IF 8.5 1区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

Cardiovascular Diabetology Pub Date : 2024-09-28 DOI:10.1186/s12933-024-02434-5

Haixiang Zheng, Leonardo Antonio Sechi, Eliano Pio Navarese, Gavino Casu, Gianpaolo Vidili

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Abstract

Metabolic dysfunction-associated steatotic liver disease (MASLD), previously termed nonalcoholic fatty liver disease (NAFLD), poses a significant global health challenge due to its increasing prevalence and strong association with cardiovascular disease (CVD). This comprehensive review summarizes the current knowledge on the MASLD-CVD relationship, compares analysis of how different terminologies for fatty liver disease affect cardiovascular (CV) risk assessment using different diagnostic criteria, explores the pathophysiological mechanisms connecting MASLD to CVD, the influence of MASLD on traditional CV risk factors, the role of noninvasive imaging techniques and biomarkers in the assessment of CV risk in patients with MASLD, and the implications for clinical management and prevention strategies. By incorporating current research and clinical guidelines, this review provides a comprehensive overview of the complex interplay between MASLD and cardiovascular health.

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代谢功能障碍相关脂肪肝与心血管风险：综合综述。

代谢功能障碍相关性脂肪性肝病（MASLD）以前被称为非酒精性脂肪肝（NAFLD），由于其发病率越来越高且与心血管疾病（CVD）密切相关，因此对全球健康构成了重大挑战。这篇综合性综述总结了当前有关 MASLD 与心血管疾病关系的知识，比较分析了脂肪肝的不同术语如何影响使用不同诊断标准进行的心血管疾病（CV）风险评估，探讨了 MASLD 与心血管疾病相关的病理生理机制、MASLD 对传统 CV 风险因素的影响、无创成像技术和生物标志物在评估 MASLD 患者 CV 风险中的作用，以及对临床管理和预防策略的影响。本综述结合了当前的研究和临床指南，全面概述了 MASLD 与心血管健康之间复杂的相互作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cardiovascular Diabetology 医学-内分泌学与代谢

CiteScore

12.30

自引率

15.10%

发文量

240

审稿时长

1 months

期刊介绍： Cardiovascular Diabetology is a journal that welcomes manuscripts exploring various aspects of the relationship between diabetes, cardiovascular health, and the metabolic syndrome. We invite submissions related to clinical studies, genetic investigations, experimental research, pharmacological studies, epidemiological analyses, and molecular biology research in this field.