Relationship of Inotropic Effects of Stimulation of β₁- and β₂-Adrenergic Receptors of Isolated Myocardial Fragments with Echocardiography Parameters in Coronary Heart Disease.

IF 0.9 4区医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL

Bulletin of Experimental Biology and Medicine Pub Date : 2024-09-01 Epub Date: 2024-09-30 DOI:10.1007/s10517-024-06235-4

S A Afanasiev, D S Kondratieva, E F Muslimova, V A Korepanov, S L Andreev, Sh D Akhmedov

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Abstract

We studied the relationship of inotropic responses of the isolated myocardium to stimulation of β₁-and β₂-adrenergic receptors (β-AR) with echocardiography parameters in 28 patients with coronary heart disease (CHD). Myocardial fragments (trabeculae of the right atrial appendage) were obtained during coronary artery bypass surgery. The inotropic response of the trabeculae was assessed in an isometric mode. Stimulation of β₁-and β₂-AR with agonists was performed against the background of preliminary α-AR blockade. In case of preserved ejection fraction, significant inotropic response of the trabeculae (135 (112; 154)% from the initial contraction amplitude) was observed after β₁-AR stimulation, while in reduced ejection fraction, its significant increase was observed after β₁-AR stimulation (126 (112; 170)% from the initial contraction amplitude). In patients with preserved and reduced ejection fraction, the correlations between the inotropic responses of the trabeculae to β₁-and β₂-AR stimulation and echocardiography parameters were different. The revealed differences reflect the degree of cardiac remodeling under condition of the studied pathology.

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刺激分离心肌片段的β1-和β2-肾上腺素能受体的肌力作用与冠心病超声心动图参数的关系

我们研究了28名冠心病（CHD）患者离体心肌对β1和β2肾上腺素能受体（β-AR）刺激的肌力反应与超声心动图参数的关系。心肌碎片（右心房阑尾小梁）是在冠状动脉搭桥手术中获得的。在等长模式下评估了小梁的肌力反应。在初步阻断α-AR的背景下，用激动剂刺激β1和β2-AR。在射血分数保留的情况下，β1-AR 刺激后可观察到小梁明显的肌力反应（与初始收缩幅度相比为 135 (112; 154)%），而在射血分数降低的情况下，β1-AR 刺激后可观察到小梁明显的肌力反应（与初始收缩幅度相比为 126 (112; 170)%）。在射血分数保留和降低的患者中，小梁对β1和β2-AR刺激的肌力反应与超声心动图参数之间的相关性不同。这些差异反映了在所研究的病理条件下心脏重塑的程度。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Bulletin of Experimental Biology and Medicine 医学-医学：研究与实验

CiteScore

1.50

自引率

14.30%

发文量

265

审稿时长

2 months

期刊介绍： Bulletin of Experimental Biology and Medicine presents original peer reviewed research papers and brief reports on priority new research results in physiology, biochemistry, biophysics, pharmacology, immunology, microbiology, genetics, oncology, etc. Novel trends in science are covered in new sections of the journal - Biogerontology and Human Ecology - that first appeared in 2005. World scientific interest in stem cells prompted inclusion into Bulletin of Experimental Biology and Medicine a quarterly scientific journal Cell Technologies in Biology and Medicine (a new Russian Academy of Medical Sciences publication since 2005). It publishes only original papers from the leading research institutions on molecular biology of stem and progenitor cells, stem cell as the basis of gene therapy, molecular language of cell-to-cell communication, cytokines, chemokines, growth and other factors, pilot projects on clinical use of stem and progenitor cells. The Russian Volume Year is published in English from April.