Ototoxic Effect of Nicotinamide Riboside.

IF 0.9 4区医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL

Bulletin of Experimental Biology and Medicine Pub Date : 2024-09-01 Epub Date: 2024-09-28 DOI:10.1007/s10517-024-06240-7

S A Ivanov, E Yu Podyacheva, S G Zhuravskii, Ya G Toropova

引用次数: 0

Abstract

We studied the function of the auditory system in Wistar rats after repeated intravenous administration of nicotinamide riboside (NR). The functional activity of the receptor and retrocochlear parts of the auditory system were assessed by recording short-latency auditory evoked potentials (SLAEPs) and distortion-product otoacoustic emissions (DPOAEs) at baseline, immediately after NR administration, and 1 and 2 months later. Repeated intravenous NR administration (cumulative dose of 2700 mg/kg) to Wistar rats has a detrimental impact on the structures within the cochlear section of the auditory system.

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烟酰胺核苷的耳毒性效应

我们研究了反复静脉注射烟酰胺核苷（NR）后 Wistar 大鼠听觉系统的功能。通过记录基线、服用 NR 后立即以及 1 个月和 2 个月后的短时听觉诱发电位 (SLAEP) 和失真产物耳声发射 (DPOAE)，评估了听觉系统受体和耳蜗后部的功能活动。对 Wistar 大鼠反复静脉注射 NR（累积剂量为 2700 毫克/千克）会对听觉系统耳蜗部分的结构产生有害影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Bulletin of Experimental Biology and Medicine 医学-医学：研究与实验

CiteScore

1.50

自引率

14.30%

发文量

265

审稿时长

2 months

期刊介绍： Bulletin of Experimental Biology and Medicine presents original peer reviewed research papers and brief reports on priority new research results in physiology, biochemistry, biophysics, pharmacology, immunology, microbiology, genetics, oncology, etc. Novel trends in science are covered in new sections of the journal - Biogerontology and Human Ecology - that first appeared in 2005. World scientific interest in stem cells prompted inclusion into Bulletin of Experimental Biology and Medicine a quarterly scientific journal Cell Technologies in Biology and Medicine (a new Russian Academy of Medical Sciences publication since 2005). It publishes only original papers from the leading research institutions on molecular biology of stem and progenitor cells, stem cell as the basis of gene therapy, molecular language of cell-to-cell communication, cytokines, chemokines, growth and other factors, pilot projects on clinical use of stem and progenitor cells. The Russian Volume Year is published in English from April.