A review on the consequences of molecular and genomic alterations following exposure to electromagnetic fields: Remodeling of neuronal network and cognitive changes

IF 3.5 3区医学 Q2 NEUROSCIENCES

Brain Research Bulletin Pub Date : 2024-09-29 DOI:10.1016/j.brainresbull.2024.111090

Shima Abtin , Fatemehsadat Seyedaghamiri , Zahra Aalidaeijavadi , Amir Mohammad Farrokhi , Fazel Moshrefi , Tayebeh Ziveh , Mohammad Ismail Zibaii , Hadi Aliakbarian , Mostafa Rezaei-Tavirani , Abbas Haghparast

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引用次数: 0

Abstract

The use of electromagnetic fields (EMFs) is essential in daily life. Since 1970, concerns have grown about potential health hazards from EMF. Exposure to EMF can stimulate nerves and affect the central nervous system, leading to neurological and cognitive changes. However, current research results are often vague and contradictory. These effects include changes in memory and learning through changes in neuronal plasticity in the hippocampus, synapses and hippocampal neuritis, and changes in metabolism and neurotransmitter levels. Prenatal exposure to EMFs has negative effects on memory and learning, as well as changes in hippocampal neuron density and histomorphology of hippocampus. EMF exposure also affects the structure and function of glial cells, affecting gate dynamics, ion conduction, membrane concentration, and protein expression. EMF exposure affects gene expression and may change epigenetic regulation through effects on DNA methylation, histone modification, and microRNA biogenesis, and potentially leading to biological changes. Therefore, exposure to EMFs possibly leads to changes in cellular and molecular mechanisms in central nervous system and alter cognitive function.

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关于暴露于电磁场后分子和基因组变化后果的综述：神经元网络重塑和认知变化。

电磁场（EMF）的使用在日常生活中必不可少。自 1970 年以来，人们越来越关注电磁场对健康的潜在危害。暴露在电磁场中会刺激神经，影响中枢神经系统，导致神经和认知能力的改变。然而，目前的研究结果往往含糊不清、自相矛盾。这些影响包括通过改变海马体、突触和海马神经炎的神经元可塑性来改变记忆和学习，以及改变新陈代谢和神经递质水平。产前接触电磁场会对记忆和学习产生负面影响，并改变海马神经元密度和海马组织形态。暴露于电磁场还会影响神经胶质细胞的结构和功能，影响栅极动态、离子传导、膜浓度和蛋白质表达。暴露于电磁场会影响基因表达，并可能通过影响 DNA 甲基化、组蛋白修饰和 microRNA 生物生成而改变表观遗传调控，并可能导致生物变化。因此，暴露于电磁场可能导致中枢神经系统的细胞和分子机制发生变化，并改变认知功能。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Brain Research Bulletin 医学-神经科学

CiteScore

6.90

自引率

2.60%

发文量

253

审稿时长

67 days

期刊介绍： The Brain Research Bulletin (BRB) aims to publish novel work that advances our knowledge of molecular and cellular mechanisms that underlie neural network properties associated with behavior, cognition and other brain functions during neurodevelopment and in the adult. Although clinical research is out of the Journal''s scope, the BRB also aims to publish translation research that provides insight into biological mechanisms and processes associated with neurodegeneration mechanisms, neurological diseases and neuropsychiatric disorders. The Journal is especially interested in research using novel methodologies, such as optogenetics, multielectrode array recordings and life imaging in wild-type and genetically-modified animal models, with the goal to advance our understanding of how neurons, glia and networks function in vivo.