Indices and ferritin level that predict organ involvement in adult-onset Still's disease.

IF 1.9 4区医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Biomarkers in medicine Pub Date : 2024-01-01 Epub Date: 2024-09-24 DOI:10.1080/17520363.2024.2403330

Mehmet Nur Kaya, Özlem Kılıç, Ezgi Çimen Güneş, Duygu Tecer, Sedat Yılmaz

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引用次数: 0

Abstract

Aim: The aim of the study is to evaluate whether C-reactive protein to albumin ratio (CAR), lactate dehydrogenase to albumin ratio (LAR), ferritin to erythrocyte sedimentation rate ratio (FER), systemic immune-inflammation index (SII), prognostic nutritional index (PNI) indices and ferritin level can predict organ involvement in adult-onset Still's disease (AOSD) patients.Methods: This study was planned as a cross-sectional study. Univariate and multivariate logistic regression analyses were performed to evaluate the usefulness of ferritin level and inflammatory indices in defining organ involvement.Results: Sixty-one patients diagnosed with AOSD were included in this study. Multivariate logistic regression analyzes showed that LAR (OR 1.028, 95% CI: 1.011-1.044) (p = 0.001) index predicted lymphadenopathy involvement, CAR (OR 1.249, 95% CI: 1.087-1.435) (p = 0.002) index predicted hepatomegaly involvement, ferritin level (OR 1.004, 95% CI: 1.001-1.008) (p = 0.007) predicted splenomegaly involvement, FER (OR 1.085, 95% CI: 1.012-1.164) (p = 0.021) and PNI (OR 0.271, 95% CI: 1.132-0.553) (p < 0.001) index predicted the occurrence of serositis.Conclusion: This study showed that ferritin level, CAR, FER, PNI and LAR markers may predict organ involvement at diagnosis in AOSD patients.

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预测成人型斯蒂尔病器官受累的指标和铁蛋白水平。

目的：本研究旨在评估 C 反应蛋白与白蛋白比值（CAR）、乳酸脱氢酶与白蛋白比值（LAR）、铁蛋白与红细胞沉降率比值（FER）、全身免疫炎症指数（SII）、预后营养指数（PNI）和铁蛋白水平能否预测成年型斯蒂尔病（AOSD）患者的器官受累情况：本研究为横断面研究。对铁蛋白水平和炎症指标进行单变量和多变量逻辑回归分析，以评估它们在确定器官受累方面的作用：本研究共纳入 61 名确诊为 AOSD 的患者。多变量逻辑回归分析显示，LAR（OR 1.028，95% CI：1.011-1.044）（P = 0.001）指数可预测淋巴腺病变，CAR（OR 1.249，95% CI：1.087-1.435）（P = 0.002）指数预测肝肿大受累情况，铁蛋白水平（OR 1.004，95% CI：1.001-1.008）（P = 0.007）预测脾肿大受累情况，FER（OR 1.085，95% CI：1.012-1.164）（P = 0.021）和 PNI（OR 0.271，95% CI：1.132-0.553）（P 结论：本研究表明，铁蛋白水平、CAR、FER、PNI 和 LAR 标志物可预测 AOSD 患者诊断时的器官受累情况。

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来源期刊

Biomarkers in medicine 医学-医学：研究与实验

CiteScore

3.80

自引率

4.50%

发文量

审稿时长

6-12 weeks

期刊介绍： Biomarkers are physical, functional or biochemical indicators of physiological or disease processes. These key indicators can provide vital information in determining disease prognosis, in predicting of response to therapies, adverse events and drug interactions, and in establishing baseline risk. The explosion of interest in biomarker research is driving the development of new predictive, diagnostic and prognostic products in modern medical practice, and biomarkers are also playing an increasingly important role in the discovery and development of new drugs. For the full utility of biomarkers to be realized, we require greater understanding of disease mechanisms, and the interplay between disease mechanisms, therapeutic interventions and the proposed biomarkers. However, in attempting to evaluate the pros and cons of biomarkers systematically, we are moving into new, challenging territory. Biomarkers in Medicine (ISSN 1752-0363) is a peer-reviewed, rapid publication journal delivering commentary and analysis on the advances in our understanding of biomarkers and their potential and actual applications in medicine. The journal facilitates translation of our research knowledge into the clinic to increase the effectiveness of medical practice. As the scientific rationale and regulatory acceptance for biomarkers in medicine and in drug development become more fully established, Biomarkers in Medicine provides the platform for all players in this increasingly vital area to communicate and debate all issues relating to the potential utility and applications. Each issue includes a diversity of content to provide rounded coverage for the research professional. Articles include Guest Editorials, Interviews, Reviews, Research Articles, Perspectives, Priority Paper Evaluations, Special Reports, Case Reports, Conference Reports and Company Profiles. Review coverage is divided into themed sections according to area of therapeutic utility with some issues including themed sections on an area of topical interest. Biomarkers in Medicine provides a platform for commentary and debate for all professionals with an interest in the identification of biomarkers, elucidation of their role and formalization and approval of their application in modern medicine. The audience for Biomarkers in Medicine includes academic and industrial researchers, clinicians, pathologists, clinical chemists and regulatory professionals.