Synergistic effect of cerium chloride and calcium chloride alters calcium signaling in keratinocytes to promote epidermal differentiation.

IF 1.4 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Bioscience, Biotechnology, and Biochemistry Pub Date : 2024-11-22 DOI:10.1093/bbb/zbae131

Kei Tsukui, Masamitsu Suzuki, Miyu Amma, Yoshihiro Tokudome

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引用次数: 0

Abstract

Epidermal keratinocytes undergo morphological and functional changes during differentiation, eventually being enucleated to become corneocytes. Calcium has been shown to be involved in various cellular functions of epidermal cells, including proliferation, differentiation, and apoptosis. Cerium is a lanthanide-series element and rare earth metal. For skin, cerium oxide has been investigated for use in absorbing UV and promoting wound healing. However, the functions and physiological effects of inorganic cerium on the skin have rarely been investigated. Here, we focused on cerium's function in epidermal keratinocytes and its interaction with calcium by investigating their effects on cell differentiation and intracellular calcium concentration. This study showed that applying cerium chloride to epidermal keratinocytes altered calcium signaling. It also suggested that cerium and calcium induced an increase in intracellular calcium concentration and promoted keratinocyte differentiation.

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氯化铈和氯化钙的协同效应可改变角质形成细胞中的钙信号转导，促进表皮分化。

表皮角质细胞在分化过程中会发生形态和功能上的变化，最终变成角质细胞。研究表明，钙参与表皮细胞的各种细胞功能，包括增殖、分化和凋亡。铈是一种镧系元素和稀土金属。在皮肤方面，氧化铈已被研究用于吸收紫外线和促进伤口愈合。然而，人们很少研究无机铈对皮肤的功能和生理效应。在这里，我们通过研究铈对细胞分化和细胞内钙浓度的影响，重点研究了铈在表皮角质细胞中的功能及其与钙的相互作用。这项研究表明，将氯化铈应用于表皮角质细胞会改变钙信号转导。研究还表明，铈和钙可诱导细胞内钙浓度的增加，促进角质形成细胞的分化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Bioscience, Biotechnology, and Biochemistry 生物-生化与分子生物学

CiteScore

3.50

自引率

0.00%

发文量

183

审稿时长

1 months

期刊介绍： Bioscience, Biotechnology, and Biochemistry publishes high-quality papers providing chemical and biological analyses of vital phenomena exhibited by animals, plants, and microorganisms, the chemical structures and functions of their products, and related matters. The Journal plays a major role in communicating to a global audience outstanding basic and applied research in all fields subsumed by the Japan Society for Bioscience, Biotechnology, and Agrochemistry (JSBBA).