Gamma-glutamyl transferase to aspartate aminotransferase ratio (GSR) predicts prognoses in patients with colorectal cancer with liver metastasis after microwave ablation.

IF 2.5 3区医学 Q2 GASTROENTEROLOGY & HEPATOLOGY

BMC Gastroenterology Pub Date : 2024-09-30 DOI:10.1186/s12876-024-03419-0

Mingzhe Huang, Zhiliang Chen, Si Qin, Jiaming Zhou, Yan Huang, Shaoyong Peng, Pinzhu Huang, Yi Lin, Maram Alenzi, Jun Huang, Jing Lin, Zhiyong Chen, Meijin Huang, Guangjian Liu

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引用次数: 0

Abstract

Background: Microwave ablation (MWA) is widely used to eliminate colorectal liver metastases (CRLM). However, the risk of tumor recurrence is difficult to predict due to lack of reliable clinical and biological markers. Elevation of gamma-glutamyl transferase (GGT) and aspartate transaminase (AST) provides signals for liver inflammation and cancer progression. The present study evaluated the association between pre-ablation GGT to AST ratio index (GSR) and hepatic recurrence in patients with CRLM after MWA.

Methods: A retrospectively analyzed 192 CRLM patients who underwent MWA from January 2013 to December 2017. Pre-ablation GSR was classified into high (≤ 2.34) or low (> 2.34) using the upper quartile value. The prognostic value of GSR and other risk factors for liver progression-free survival (LPFS) and cancer-specific survival (CSS) were evaluated by univariate and multivariate analyses.

Results: High GSR was significantly associated with males (P = 0.041), the presence of cholelithiasis (P = 0.012), but not pre-ablation chemotherapy (P = 0.355), which caused significantly increased levels of GGT (P = 0.015) and AST (P = 0.008). GSR showed a significant association with LPFS and CSS through univariate analysis (P = 0.002 and 0.006) and multivariate analysis (P = 0.043 and 0.037). The subgroup analysis demonstrated no interaction between GSR and all variables except for distribution in the sub-analysis of LPFS.

Conclusions: Our findings suggest that the pre-ablation GSR can be considered as a promising prognostic indicator for poor prognosis of patients with CRLM underwent MWA.

Trial registration: Not applicable.

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γ-谷氨酰转移酶与天冬氨酸氨基转移酶比值（GSR）可预测微波消融术后肝转移的结直肠癌患者的预后。

背景：微波消融术（MWA）被广泛用于消除结直肠肝转移瘤（CRLM）。然而，由于缺乏可靠的临床和生物学指标，肿瘤复发的风险难以预测。γ-谷氨酰转移酶（GGT）和天冬氨酸转氨酶（AST）的升高提供了肝脏炎症和癌症进展的信号。本研究评估了MWA术后CRLM患者消融前GGT与AST比值指数（GSR）与肝复发之间的关系：回顾性分析了2013年1月至2017年12月期间接受MWA的192例CRLM患者。以上四分位值将消融前GSR分为高（≤2.34）和低（>2.34）。通过单变量和多变量分析评估了GSR和其他风险因素对肝脏无进展生存期（LPFS）和癌症特异性生存期（CSS）的预后价值：高GSR与男性（P = 0.041）、胆石症（P = 0.012）明显相关，但与消融前化疗（P = 0.355）无关，化疗会导致GGT（P = 0.015）和AST（P = 0.008）水平明显升高。通过单变量分析（P = 0.002 和 0.006）和多变量分析（P = 0.043 和 0.037），GSR 与 LPFS 和 CSS 有明显关系。亚组分析表明，除LPFS亚组分析中的分布外，GSR与所有变量之间均无交互作用：我们的研究结果表明，对于接受MWA治疗的CRLM患者，消融前GSR可被视为预后不良的一个有希望的预后指标：不适用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMC Gastroenterology 医学-胃肠肝病学

CiteScore

4.20

自引率

0.00%

发文量

465

审稿时长

6 months

期刊介绍： BMC Gastroenterology is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of gastrointestinal and hepatobiliary disorders, as well as related molecular genetics, pathophysiology, and epidemiology.