Seroprotection against tetanus in HIV-exposed and HIV-unexposed infants in Malawi in 2019-2020.

IF 2 4区医学 Q2 PEDIATRICS

BMJ Paediatrics Open Pub Date : 2024-09-24 DOI:10.1136/bmjpo-2024-002718

Silvia Baroncelli, Clementina Maria Galluzzo, Stefano Orlando, Richard Luhanga, Robert Mphwere, Thom Kavalo, Roberta Amici, Marco Floridia, Mauro Andreotti, Fausto Ciccacci, Maria Cristina Marazzi, Marina Giuliano

引用次数: 0

Abstract

In Malawi, tetanus toxoid vaccination (TTV) is recommended in pregnancy, but few studies have assessed the prevalence of infant seroprotection against tetanus. Anti-TT levels from 84 6-week-old infants, born in 2019-2020 to mothers living with HIV (HEU: HIV-exposed-uninfected) infants and to HIV-negative women (HUU: HIV-unexposed-uninfected) infants were determined by ELISA assay. Although 94% of the infants (HEU=94.8%, HUU=92.3%) showed protective levels (>0.1 IU/mL), the mean titers observed (0.51 IU/mL) suggest an incomplete compliance with TT vaccination. The only factor positively correlated to anti-TT IgG levels was the duration of maternal antiretroviral therapy in HEU.

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2019-2020 年马拉维感染艾滋病毒和未感染艾滋病毒婴儿的破伤风血清保护。

马拉维建议孕妇接种破伤风类毒素疫苗（TTV），但很少有研究对婴儿破伤风血清保护率进行评估。本研究采用 ELISA 法测定了 84 名 6 周大婴儿的抗-TT 水平，这些婴儿分别出生于 2019-2020 年，其母亲为 HIV 感染者（HEU：HIV 暴露-未感染），母亲为 HIV 阴性女性（HU：HIV 未暴露-未感染）。尽管 94% 的婴儿（HEU=94.8%，HUU=92.3%）显示出保护性水平（>0.1 IU/mL），但观察到的平均滴度（0.51 IU/mL）表明 TT 疫苗接种未完全达标。唯一与抗 TT IgG 水平呈正相关的因素是 HEU 中母体抗逆转录病毒治疗的持续时间。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMJ Paediatrics Open Medicine-Pediatrics, Perinatology and Child Health

CiteScore

4.10

自引率

3.80%

发文量

124