Time-Restricted Eating in Adults With Metabolic Syndrome : A Randomized Controlled Trial.

IF 19.6 1区医学 Q1 MEDICINE, GENERAL & INTERNAL

Annals of Internal Medicine Pub Date : 2024-11-01 Epub Date: 2024-10-01 DOI:10.7326/M24-0859

Emily N C Manoogian, Michael J Wilkinson, Monica O'Neal, Kyla Laing, Justina Nguyen, David Van, Ashley Rosander, Aryana Pazargadi, Nikko R Gutierrez, Jason G Fleischer, Shahrokh Golshan, Satchidananda Panda, Pam R Taub

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引用次数: 0

Abstract

Background: Time-restricted eating (TRE), limiting daily dietary intake to a consistent 8 to 10 hours without mandating calorie reduction, may provide cardiometabolic benefits.

Objective: To determine the effects of TRE as a lifestyle intervention combined with current standard-of-care treatments on cardiometabolic health in adults with metabolic syndrome.

Design: Randomized controlled trial. (ClinicalTrials.gov: NCT04057339).

Setting: Clinical research institute.

Participants: Adults with metabolic syndrome including elevated fasting glucose or hemoglobin A_1c (HbA_1c; pharmacotherapy allowed).

Intervention: Participants were randomly assigned to standard-of-care (SOC) nutritional counseling alone (SOC group) or combined with a personalized 8- to 10-hour TRE intervention (≥4-hour reduction in eating window) (TRE group) for 3 months. Timing of dietary intake was tracked in real time using the myCircadianClock smartphone application.

Measurements: Primary outcomes were HbA_1c, fasting glucose, fasting insulin, homeostasis model assessment of insulin resistance, and glycemic assessments from continuous glucose monitors.

Results: 108 participants from the TIMET study completed the intervention (89% of those randomly assigned; 56 women, mean baseline age, 59 years; body mass index of 31.22 kg/m²; eating window of 14.19 hours). Compared with SOC, TRE improved HbA_1c by -0.10% (95% CI, -0.19% to -0.003%). Statistical outcomes were adjusted for age. There were no major adverse events.

Limitation: Short duration, self-reported diet, potential for multiple elements affecting outcomes.

Conclusion: Personalized 8- to 10-hour TRE is an effective practical lifestyle intervention that modestly improves glycemic regulation and may have broader benefits for cardiometabolic health in adults with metabolic syndrome on top of SOC pharmacotherapy and nutritional counseling.

Primary funding source: National Institutes of Health.

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成人代谢综合征患者的限时进食：随机对照试验。

背景：限时进食（TRE）是指在不强制减少卡路里的情况下，将每日饮食摄入量限制在8至10小时内，这可能会对心脏代谢产生益处：目的：确定限时进食作为一种生活方式干预措施，结合目前的标准治疗方法，对患有代谢综合征的成年人的心脏代谢健康有何影响：设计：随机对照试验。(设计：随机对照试验（ClinicalTrials.gov：NCT04057339）：临床研究机构：成人代谢综合征患者，包括空腹血糖或血红蛋白 A1c（HbA1c；允许药物治疗）升高：参与者被随机分配到单独的标准护理（SOC）营养咨询（SOC 组）或结合个性化的 8-10 小时 TRE 干预（进食时间≥4 小时）（TRE 组），为期 3 个月。使用 myCircadianClock 智能手机应用程序实时跟踪饮食摄入时间：主要结果为 HbA1c、空腹血糖、空腹胰岛素、胰岛素抵抗平衡模型评估以及连续血糖监测仪的血糖评估：108 名 TIMET 研究参与者完成了干预（占随机分配人数的 89%；56 名女性，平均基线年龄为 59 岁；体重指数为 31.22 kg/m2；进食时间为 14.19 小时）。与 SOC 相比，TRE 将 HbA1c 改善了-0.10%（95% CI，-0.19% 至-0.003%）。统计结果根据年龄进行了调整。无重大不良反应：局限性：持续时间短，自我报告饮食，可能有多种因素影响结果：个性化 8 至 10 小时 TRE 是一种有效的实用生活方式干预措施，可适度改善血糖调节，并在 SOC 药物治疗和营养咨询的基础上，对患有代谢综合征的成年人的心脏代谢健康产生更广泛的益处：主要资金来源：美国国立卫生研究院。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annals of Internal Medicine 医学-医学：内科

CiteScore

23.90

自引率

1.80%

发文量

1136

审稿时长

3-8 weeks

期刊介绍： Established in 1927 by the American College of Physicians (ACP), Annals of Internal Medicine is the premier internal medicine journal. Annals of Internal Medicine’s mission is to promote excellence in medicine, enable physicians and other health care professionals to be well informed members of the medical community and society, advance standards in the conduct and reporting of medical research, and contribute to improving the health of people worldwide. To achieve this mission, the journal publishes a wide variety of original research, review articles, practice guidelines, and commentary relevant to clinical practice, health care delivery, public health, health care policy, medical education, ethics, and research methodology. In addition, the journal publishes personal narratives that convey the feeling and the art of medicine.