Applications of Digital Enzyme-Linked Immunosorbent Assays in Ophthalmology.

IF 1.8 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Cell Biochemistry and Biophysics Pub Date : 2024-09-27 DOI:10.1007/s12013-024-01515-2

He Yu, Jiaping Song, Junrong Li, Yuanyuan Qi, Zhe Fan, Qiming Liu, Liang Yu, Jian Song, He Dong

引用次数: 0

Abstract

Digital enzyme-linked immunosorbent assays (dELISAs) very sensitively detect biomarkers that cannot be measured using traditional methods. The molecules are confined within a small volume, their counts accurately computed, and the results rapidly delivered. Digital ELISAs find many applications. In recent years, such ELISAs have become increasingly used to aid ophthalmological diagnoses and treatments, and have revolutionized the field. This article reviews the applications of dELISAs in clinical practice, especially in the sphere of ophthalmology.

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数字酶联免疫吸附测定在眼科中的应用。

数字酶联免疫吸附试验（dELISAs）能非常灵敏地检测出传统方法无法测量的生物标记物。分子被限制在一个很小的体积内，它们的计数被精确计算，结果也能迅速送达。数字酶联免疫吸附测定法应用广泛。近年来，这种酶联免疫吸附试验越来越多地用于眼科诊断和治疗，并在该领域掀起了一场革命。本文回顾了 dELISAs 在临床实践中的应用，尤其是在眼科领域的应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell Biochemistry and Biophysics 生物-生化与分子生物学

CiteScore

4.40

自引率

0.00%

发文量

审稿时长

7.5 months

期刊介绍： Cell Biochemistry and Biophysics (CBB) aims to publish papers on the nature of the biochemical and biophysical mechanisms underlying the structure, control and function of cellular systems The reports should be within the framework of modern biochemistry and chemistry, biophysics and cell physiology, physics and engineering, molecular and structural biology. The relationship between molecular structure and function under investigation is emphasized. Examples of subject areas that CBB publishes are: · biochemical and biophysical aspects of cell structure and function; · interactions of cells and their molecular/macromolecular constituents; · innovative developments in genetic and biomolecular engineering; · computer-based analysis of tissues, cells, cell networks, organelles, and molecular/macromolecular assemblies; · photometric, spectroscopic, microscopic, mechanical, and electrical methodologies/techniques in analytical cytology, cytometry and innovative instrument design For articles that focus on computational aspects, authors should be clear about which docking and molecular dynamics algorithms or software packages are being used as well as details on the system parameterization, simulations conditions etc. In addition, docking calculations (virtual screening, QSAR, etc.) should be validated either by experimental studies or one or more reliable theoretical cross-validation methods.