Efficient PROTAC-ing: combinational use of PROTACs with signaling pathway inhibitors.

IF 3.5 2区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

ACS Chemical Biology Pub Date : 2024-11-01 Epub Date: 2024-09-26 DOI:10.1016/j.tibs.2024.09.002

Yuri Shibata

引用次数: 0

Abstract

Targeted protein degradation is an innovative therapeutic modality for the degradation of disease-causing proteins. In a recent report combining high-throughput screening of small-molecule compounds and biochemical analyses, Mori et al. identified certain inhibitors of cellular pathways, such as PARylation and proteostatic pathways, which enhance proteolysis-targeting chimera (PROTAC)-induced protein degradation.

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高效 PROTAC-ing：将 PROTAC 与信号通路抑制剂结合使用。

靶向蛋白质降解是降解致病蛋白质的一种创新疗法。最近，Mori 等人结合小分子化合物的高通量筛选和生化分析，发现了某些细胞通路（如 PARylation 和蛋白静态通路）的抑制剂，这些抑制剂能增强蛋白水解靶向嵌合体（PROTAC）诱导的蛋白质降解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Chemical Biology 生物-生化与分子生物学

CiteScore

7.50

自引率

5.00%

发文量

353

审稿时长

3.3 months

期刊介绍： ACS Chemical Biology provides an international forum for the rapid communication of research that broadly embraces the interface between chemistry and biology. The journal also serves as a forum to facilitate the communication between biologists and chemists that will translate into new research opportunities and discoveries. Results will be published in which molecular reasoning has been used to probe questions through in vitro investigations, cell biological methods, or organismic studies. We welcome mechanistic studies on proteins, nucleic acids, sugars, lipids, and nonbiological polymers. The journal serves a large scientific community, exploring cellular function from both chemical and biological perspectives. It is understood that submitted work is based upon original results and has not been published previously.