Unraveling the role of cholecystokinin in epilepsy: Mechanistic insight into neuroplasticity

IF 4.4 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Neurochemistry international Pub Date : 2024-09-28 DOI:10.1016/j.neuint.2024.105870

Muhammad Asim , Gao Qianqian , Abdul Waris , Huajie Wang , Yuanying Lai , Xi Chen

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Abstract

Epilepsy is a disorder characterized by an imbalance between excitability and inhibition, leading to uncontrolled hyperexcitability of neurons in the central nervous system. Despite the prevalence of epileptic seizures, the underlying mechanisms driving this hyperexcitability remain poorly understood. This review article aims to enhance our understanding of the mechanisms of epilepsy, with a specific focus on the role of cholecystokinin (CCK) in this debilitating disease. We will begin with an introduction to the topic, followed by an examination of the role of GABAergic neurons and the synaptic plasticity mechanisms associated with seizures. As we delve deeper, we will elucidate how CCK and its receptors contribute to seizure behavior. Finally, we will discuss the CCK-dependent synaptic plasticity mechanisms and highlight their potential implications in seizure activity. Through a comprehensive examination of these aspects, this review provides valuable insights into the involvement of CCK and its receptors in epilepsy. By improving our understanding of the mechanisms underlying this condition, particularly the role of CCK, we aim to contribute to the development of more effective treatment strategies.

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揭示胆囊收缩素在癫痫中的作用：神经可塑性的机制启示。

癫痫是一种以兴奋性和抑制性失衡为特征的疾病，会导致中枢神经系统的神经元出现不受控制的过度兴奋。尽管癫痫发作十分普遍，但人们对这种过度兴奋的内在机制仍然知之甚少。这篇综述文章旨在加深我们对癫痫机制的了解，并特别关注胆囊收缩素（CCK）在这一使人衰弱的疾病中的作用。我们将首先介绍这一主题，然后探讨 GABA 能神经元的作用以及与癫痫发作相关的突触可塑性机制。随着研究的深入，我们将阐明 CCK 及其受体如何对癫痫发作行为产生影响。最后，我们将讨论依赖 CCK 的突触可塑性机制，并强调其在癫痫发作活动中的潜在影响。通过对这些方面的全面研究，本综述为了解 CCK 及其受体在癫痫中的作用提供了宝贵的见解。我们希望通过加深对癫痫发病机制的了解，特别是对CCK作用的了解，为制定更有效的治疗策略做出贡献。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neurochemistry international 医学-神经科学

CiteScore

8.40

自引率

2.40%

发文量

128

审稿时长

37 days

期刊介绍： Neurochemistry International is devoted to the rapid publication of outstanding original articles and timely reviews in neurochemistry. Manuscripts on a broad range of topics will be considered, including molecular and cellular neurochemistry, neuropharmacology and genetic aspects of CNS function, neuroimmunology, metabolism as well as the neurochemistry of neurological and psychiatric disorders of the CNS.