The Chemistry and Pharmacological Properties of the Constituents of Toussaintia Orientalis - An Endangered Treasure of Biomedical Agents.

IF 3 4区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

ChemPlusChem Pub Date : 2024-09-24 DOI:10.1002/cplu.202400445

Joan J E Munissi, Stephen S Nyandoro

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引用次数: 0

Abstract

Toussaintia orientalis Verdc. (Annonaceae) is a medicinal plant species endemic to Tanzania. It is classified under the International Union for Conservation of Nature (IUCN) as an extremely endangered species threatened with extinction. The review covers the phytochemistry of this plant species and the pharmacological properties of the compounds obtained therefrom. The chemistry of this plant species entails natural products with different structures including uncommon cinnamoyl tetraketide derivatives, aristolactam alkaloids, and flavonoids. The review identifies 27 compounds belonging to different subclasses of natural products obtained from this species for the past fourteen years (2010-2024). These compounds are discussed along with other 13 related natural products. T. orientalis derived compounds exhibit varied potential pharmacological applications as antibacterial, anticancer, anti-inflammatory, antiviral, and neuroprotective agents. Some of the reported compounds displayed pharmacological properties corroborating the use of this plant species in traditional medicine. This review provides baseline data as one comprehensive compilation that will ignite interest and guide future research and development of therapeutic agents inspired by the chemodiversity presented by this plant species while at the same time attracting the attention of plant conservationists to initiate efforts to conserve this highly endangered biomedical treasure.

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东方斗篷草成分的化学和药理特性--一种濒临灭绝的生物药剂宝藏。

Toussaintia orientalis Verdc.（芒萁科）是坦桑尼亚特有的一种药用植物。它被世界自然保护联盟（IUCN）列为极度濒危物种，濒临灭绝。这篇综述涵盖了该植物物种的植物化学以及从其中获得的化合物的药理特性。该植物物种的化学成分包含不同结构的天然产物，包括不常见的肉桂酰四酮衍生物、马兜铃内酰胺生物碱和黄酮类化合物。本综述确定了过去 14 年（2010-2024 年）从该物种中获得的属于不同天然产物亚类的 27 种化合物。这些化合物与其他 13 种相关天然产物一起进行了讨论。东方蓟马衍生的化合物在抗菌、抗癌、抗炎、抗病毒和神经保护剂方面具有多种潜在的药理应用。所报道的一些化合物显示出的药理特性证实了该植物物种在传统医学中的应用。这篇综述提供了全面的基础数据，将激发人们的兴趣，并指导未来研究和开发由这种植物物种所呈现的化学多样性所启发的治疗药物，同时吸引植物保护主义者的关注，以启动保护这种高度濒危的生物医学宝藏的工作。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ChemPlusChem CHEMISTRY, MULTIDISCIPLINARY-

CiteScore

5.90

自引率

0.00%

发文量

200

审稿时长

1 months

期刊介绍： ChemPlusChem is a peer-reviewed, general chemistry journal that brings readers the very best in multidisciplinary research centering on chemistry. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies. Fully comprehensive in its scope, ChemPlusChem publishes articles covering new results from at least two different aspects (subfields) of chemistry or one of chemistry and one of another scientific discipline (one chemistry topic plus another one, hence the title ChemPlusChem). All suitable submissions undergo balanced peer review by experts in the field to ensure the highest quality, originality, relevance, significance, and validity.