Histopathological Characteristics and Inflammatory Cell Infiltration in Sinonasal Inverted Papilloma.

IF 2.5 3区医学 Q1 OTORHINOLARYNGOLOGY

American Journal of Rhinology & Allergy Pub Date : 2024-09-28 DOI:10.1177/19458924241282094

Jing Qu, Yan Sun, Na Liang, Cheng Li, Qian Huang, Mingjie Wang, Deyun Wang, Bing Zhou

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引用次数: 0

Abstract

Background: Sinonasal inverted papilloma (SNIP) is a benign epithelial tumor with distinctive histopathological features. However, the role of inflammation in SNIP remains poorly characterized.

Objectives: This study aimed to compare the histopathological patterns and inflammatory characteristics of SNIP with those of chronic rhinosinusitis with nasal polyps (CRSwNPs) or normal ethmoid sinus mucosa.

Methods: Fifty-eight tissue biopsies were prospectively collected from 38 patients with SNIPs, 12 CRSwNPs, and 8 normal ethmoid sinus mucosae. SNIP was histopathologically divided into four grades based on the extent of epithelial remodeling. The immunohistochemical characteristics of epithelial remodeling (p63, CK5) and infiltration of inflammatory cells (eg, eosinophils, neutrophils, and macrophages) and cytokines (eg, interleukin-1β, interleukin-6, and tumor necrosis factor-α) were analyzed.

Results: Among the 38 SNIPs, 21.1%, 36.8%, 23.7%, and 18.4% were grades I, II, III, and IV, respectively. The expression levels of p63 and CK5 were significantly higher in SNIP than in the other two groups (both, p < 0.05). Neutrophil and macrophage infiltration was more pronounced in SNIP and with differences among the four grades. The expression levels of inflammatory cytokines were significantly higher in the SNIP group than in the CRSwNP group. A positive correlation between the expression levels of p63 and inflammatory cytokines was observed in both SNIPs and CRSwNPs.

Conclusion: Excessive epithelial remodeling is an important histological feature of SNIP; it is accompanied by sinonasal mucosal inflammation.

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鼻窦倒置乳头状瘤的组织病理学特征和炎性细胞浸润

背景：鼻窦倒置乳头状瘤（SNIP）是一种良性上皮肿瘤，具有独特的组织病理学特征。然而，炎症在鼻窦倒置乳头状瘤中的作用仍鲜为人知：本研究旨在比较 SNIP 与慢性鼻炎伴鼻息肉（CRSwNPs）或正常乙状窦粘膜的组织病理学模式和炎症特征：前瞻性地从 38 名 SNIP 患者、12 名 CRSwNP 患者和 8 名正常乙状窦粘膜患者身上采集了 58 份组织活检样本。根据上皮重塑的程度，SNIP 在组织病理学上分为四个等级。分析了上皮重塑（p63、CK5）和炎症细胞（如嗜酸性粒细胞、中性粒细胞和巨噬细胞）及细胞因子（如白细胞介素-1β、白细胞介素-6和肿瘤坏死因子-α）浸润的免疫组化特征：在 38 个 SNIPs 中，I 级、II 级、III 级和 IV 级分别占 21.1%、36.8%、23.7% 和 18.4%。在 SNIP 中，p63 和 CK5 的表达水平明显高于其他两组（均为 p 结论：SNIP 中的上皮重构过度是导致上皮细胞癌变的主要原因：上皮过度重塑是 SNIP 的一个重要组织学特征，并伴有鼻窦粘膜炎症。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American Journal of Rhinology & Allergy 医学-耳鼻喉科学

CiteScore

5.60

自引率

11.50%

发文量

审稿时长

4-8 weeks

期刊介绍： The American Journal of Rhinology & Allergy is a peer-reviewed, scientific publication committed to expanding knowledge and publishing the best clinical and basic research within the fields of Rhinology & Allergy. Its focus is to publish information which contributes to improved quality of care for patients with nasal and sinus disorders. Its primary readership consists of otolaryngologists, allergists, and plastic surgeons. Published material includes peer-reviewed original research, clinical trials, and review articles.