Differences in total plaque burden between plaque rupture and plaque erosion: A combined computed tomography angiography and optical coherence tomography study

IF 5.5 2区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

Journal of Cardiovascular Computed Tomography Pub Date : 2024-11-01 DOI:10.1016/j.jcct.2024.09.007

Takayuki Niida , Eisuke Usui , Keishi Suzuki , Daisuke Kinoshita , Haruhito Yuki , Daichi Fujimoto , Marco Covani , Damini Dey , Hang Lee , Iris McNulty , Maros Ferencik , Taishi Yonetsu , Tsunekazu Kakuta , Ik-Kyung Jang

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引用次数: 0

Abstract

Backgrounds

Coronary computed tomography angiography (CTA) allows for the assessment of atherosclerotic plaque burden across the entire coronary vasculature. No studies have examined the relationship between the underlying pathology of the culprit lesion and total plaque burden in patients with acute coronary syndromes. The aim of this study was to compare the total plaque burden between patients with plaque rupture versus plaque erosion.

Methods

A total of 232 patients who presented with their first non-ST-segment elevation acute coronary syndrome and underwent both CTA and optical coherence tomography imaging before intervention were selected. Quantitative analysis was performed using semi-automated software (Autoplaque version 3.0, Cedars-Sinai Medical Center). An attenuation of <30 Hounsfield units defined low-density non-calcified plaque (LDNCP). All 3 vessels were assessed using the modified 17-segment American Heart Association model for coronary segment classification.

Results

Among 232 patients, 125 (53.9%) had plaque rupture and 107 (46.1%) had plaque erosion. Total plaque burden (48.2 [39.8–54.9] % vs. 44.1 [38.6–50.0] %, P = 0.006), total non-calcified plaque (NCP) burden (46.6 [39.1–53.3] % vs. 43.0 [37.6–49.2] %, P = 0.013), total LDNCP burden (2.3 [1.4–3.0] % vs. 1.7 [1.2–2.6] %, P = 0.016), and total calcified plaque (CP) burden (0.8 [0.1–1.6] % vs. 0.4 [0.0–1.4] %, P = 0.047) were significantly greater in patients with culprit plaque rupture than in those with culprit plaque erosion.

Conclusion

Patients with plaque rupture, compared with those with plaque erosion, had a greater total plaque burden, NCP burden, LDNCP burden, and CP burden.

Clinical trial registration

URL: https://www.clinicaltrials.gov; Unique identifier: NCT04523194.

Abstract Image

查看原文本刊更多论文

斑块破裂与斑块侵蚀之间斑块总负荷的差异：计算机断层扫描血管造影和光学相干断层扫描联合研究。

背景：冠状动脉计算机断层扫描血管造影术（CTA）可评估整个冠状动脉血管的动脉粥样硬化斑块负荷。目前还没有研究对急性冠状动脉综合征患者的罪魁祸首病变与斑块总负荷之间的关系进行研究。本研究旨在比较斑块破裂与斑块侵蚀患者的斑块总负荷：方法：共选取了 232 例首次出现非 ST 段抬高急性冠状动脉综合征的患者，这些患者在介入治疗前均接受了 CTA 和光学相干断层扫描成像。使用半自动软件（Autoplaque 3.0 版，Cedars-Sinai 医学中心）进行定量分析。结果：在 232 名患者中，125 人（53.9%）有斑块破裂，107 人（46.1%）有斑块侵蚀。斑块总负荷（48.2 [39.8-54.9] % vs. 44.1 [38.6-50.0] %，P = 0.006）、非钙化斑块（NCP）总负荷（46.6 [39.1-53.3] % vs. 43.0 [37.6-49.2] %，P = 0.013）、LDNCP 总负荷（2.3 [1.4-3.0] % vs. 1.7 [1.2-2.6]%，P = 0.016）和总钙化斑块（CP）负荷（0.8 [0.1-1.6] % vs. 0.4 [0.0-1.4] %，P = 0.047）在斑块破裂患者中明显高于斑块侵蚀患者：结论：与斑块侵蚀患者相比，斑块破裂患者的斑块总负荷、NCP负荷、LDNCP负荷和CP负荷更大：URL: https://www.Clinicaltrials: gov; Unique identifier：NCT04523194。

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来源期刊

Journal of Cardiovascular Computed Tomography CARDIAC & CARDIOVASCULAR SYSTEMS-RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

CiteScore

7.50

自引率

14.80%

发文量

212

审稿时长

40 days

期刊介绍： The Journal of Cardiovascular Computed Tomography is a unique peer-review journal that integrates the entire international cardiovascular CT community including cardiologist and radiologists, from basic to clinical academic researchers, to private practitioners, engineers, allied professionals, industry, and trainees, all of whom are vital and interdependent members of our cardiovascular imaging community across the world. The goal of the journal is to advance the field of cardiovascular CT as the leading cardiovascular CT journal, attracting seminal work in the field with rapid and timely dissemination in electronic and print media.