The independent and joint association between physical activity, sleep duration and daily sitting time with bone mineral density: A real world study from NHANES 2007–2018.

IF 3.5 2区医学 Q2 ENDOCRINOLOGY & METABOLISM

Bone Pub Date : 2024-09-25 DOI:10.1016/j.bone.2024.117264

Hongjiang Yang , Bo Li , Hailiang Li , Mi Zhou , Baicao Li , Junrui Guo , Hao Zhong , Song Liu , Qi Zhang , Cong Xing , Guangzhi Ning

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引用次数: 0

Abstract

Purpose

To assess the independent and joint effect of physical activity, sleep duration, and daily sitting time on bone mineral density (BMD), based on National Health and Nutrition Examination Survey (NHANES) 2007–2018.

Design

Cross-sectional design.

Methods

The primary outcome was risk of low BMD. All associations between lifestyle factors and the prevalence of low BMD were based on logistic regression, and dose-response relationships were further explored by restricted cubic spline (RCS). Finally, multiplicative and additive interaction was examined by P _interaction and relative excess risk due to interaction (RERI).

Results

10,346 individuals (N _{normal BMD} = 6353; N _{Low BMD} = 3993) were analyzed. Multivariate logistic regression indicated low intensity physical activity (odds ratio [OR] 0.84; 95 % confidence interval [95%CI] 0.78–0.90) and high intensity physical activity (0.67, 0.56–0.78) had protective impact on risk of low BMD, whereas short sleep (1.41, 1.20–1.64), long sleep (1.36, 1.03–1.79) and prolonged daily sitting (1.58, 1.32–1.88) had harmful effect. RCS revealed dose-response associations between physical activity (J-shaped), sleep duration (U-shaped), daily sitting time (positive-associated) and risk of low BMD. Multiplicative interaction between sleep duration and physical activity was observed (P _interaction = 0.003), while not between daily sitting time and physical activity (P _interaction = 0.600). Notably, negative additive interactions indicated that physical activity mitigated the increased risk of low BMD associated with irregular sleep patterns and prolonged sedentary behavior.

Conclusion

Increasing physical activity was presented as a modulating factor, potentially altering the relationship between independent variables that have deleterious effects on BMD like sleep duration and sedentary behavior. The study underscores the importance of lifestyle modifications in the prevention of early onset low BMD.

Abstract Image

查看原文本刊更多论文

体育锻炼、睡眠时间和每天坐着的时间与骨矿物质密度之间的独立和联合关系：一项来自 2007-2018 年国家健康调查（NHANES）的真实世界研究。

目的：根据2007-2018年美国国家健康与营养调查（NHANES），评估体力活动、睡眠时间和每日坐姿时间对骨矿物质密度（BMD）的独立和联合影响：设计：横断面设计：主要结果是低 BMD 风险。生活方式因素与低 BMD 患病率之间的所有关联均基于逻辑回归，剂量-反应关系则通过受限立方样条曲线（RCS）进一步探讨。最后，通过P交互作用和交互作用导致的相对超额风险（RERI）检验了乘法和加法交互作用：分析了 10346 人（正常 BMD = 6353 人；低 BMD = 3993 人）。多变量逻辑回归显示，低强度体力活动（几率比 [OR] 0.84；95% 置信区间 [95%CI] 0.78-0.90）和高强度体力活动（0.67，0.56-0.78）对低 BMD 风险具有保护作用，而短睡眠（1.41，1.20-1.64）、长睡眠（1.36，1.03-1.79）和每天久坐（1.58，1.32-1.88）则具有有害作用。RCS显示，体力活动（J形）、睡眠时间（U形）、每日久坐时间（正相关）与低BMD风险之间存在剂量-反应关系。睡眠时间与体力活动之间存在乘法交互作用（P 交互作用 = 0.003），而每日久坐时间与体力活动之间不存在乘法交互作用（P 交互作用 = 0.600）。值得注意的是，负相加相互作用表明，体育锻炼可减轻与不规律睡眠模式和长期久坐行为相关的低 BMD 风险的增加：增加体育锻炼是一个调节因素，有可能改变睡眠时间和久坐行为等对 BMD 有不利影响的自变量之间的关系。这项研究强调了改变生活方式对预防早发低 BMD 的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Bone 医学-内分泌学与代谢

CiteScore

8.90

自引率

4.90%

发文量

264

审稿时长

30 days

期刊介绍： BONE is an interdisciplinary forum for the rapid publication of original articles and reviews on basic, translational, and clinical aspects of bone and mineral metabolism. The Journal also encourages submissions related to interactions of bone with other organ systems, including cartilage, endocrine, muscle, fat, neural, vascular, gastrointestinal, hematopoietic, and immune systems. Particular attention is placed on the application of experimental studies to clinical practice.