Comprehensive insights into human papillomavirus and cervical cancer: Pathophysiology, screening, and vaccination strategies

IF 11.3 1区化学 Q1 CHEMISTRY, PHYSICAL

ACS Catalysis Pub Date : 2024-09-29 DOI:10.1016/j.bbcan.2024.189192

Ying Liu, Hao Ai

引用次数: 0

Abstract

This article provides an in-depth review of the Human Papillomavirus (HPV), a predominant etiological factor in cervical cancer, exploring its pathophysiology, epidemiology, and mechanisms of oncogenesis. We examine the role of proteins, DNA methylation markers, and non-coding RNAs as predictive biomarkers in cervical cancer, highlighting their potential in refining diagnostic and prognostic practices. The evolution and efficacy of cervical cancer screening methods, including the Papanicolaou smear, HPV testing, cytology and HPV test, and colposcopy techniques, are critically analyzed. Furthermore, the article delves into the current landscape and future prospects of prophylactic HPV vaccines and therapeutic vaccines, underscoring their significance in the prevention and potential treatment of HPV-related diseases. This comprehensive review aims to synthesize recent advances and ongoing challenges in the field, providing a foundation for future research and clinical strategies in the prevention and management of cervical cancer.

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人类乳头瘤病毒与宫颈癌的全面认识：病理生理学、筛查和疫苗接种策略。

本文深入综述了宫颈癌的主要致病因素--人类乳头瘤病毒（HPV），探讨了其病理生理学、流行病学和致癌机制。我们研究了蛋白质、DNA 甲基化标记和非编码 RNA 作为宫颈癌预测性生物标记物的作用，强调了它们在完善诊断和预后实践方面的潜力。文章批判性地分析了宫颈癌筛查方法的演变和功效，包括巴氏涂片、人乳头瘤病毒检测、细胞学和人乳头瘤病毒检测以及阴道镜检查技术。此外，文章还深入探讨了预防性 HPV 疫苗和治疗性疫苗的现状和未来前景，强调了它们在预防和潜在治疗 HPV 相关疾病方面的重要意义。这篇综合评论旨在总结该领域的最新进展和当前挑战，为宫颈癌预防和管理的未来研究和临床策略奠定基础。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Catalysis CHEMISTRY, PHYSICAL-

CiteScore

20.80

自引率

6.20%

发文量

1253

审稿时长

1.5 months

期刊介绍： ACS Catalysis is an esteemed journal that publishes original research in the fields of heterogeneous catalysis, molecular catalysis, and biocatalysis. It offers broad coverage across diverse areas such as life sciences, organometallics and synthesis, photochemistry and electrochemistry, drug discovery and synthesis, materials science, environmental protection, polymer discovery and synthesis, and energy and fuels. The scope of the journal is to showcase innovative work in various aspects of catalysis. This includes new reactions and novel synthetic approaches utilizing known catalysts, the discovery or modification of new catalysts, elucidation of catalytic mechanisms through cutting-edge investigations, practical enhancements of existing processes, as well as conceptual advances in the field. Contributions to ACS Catalysis can encompass both experimental and theoretical research focused on catalytic molecules, macromolecules, and materials that exhibit catalytic turnover.