The Role of Paraclinical Investigations in Detecting Inflammation in Children and Adolescents with Obesity and Metabolic Syndrome.

IF 3.2 3区生物学 Q1 BIOLOGY

Life-Basel Pub Date : 2024-09-23 DOI:10.3390/life14091206

Mihaela-Andreea Podeanu, Ștefănița Bianca Vintilescu, Claudiu Marinel Ionele, Raluca Elena Sandu, Carmen Elena Niculescu, Mirela-Marinela Florescu, Mioara Desdemona Stepan

{"title":"The Role of Paraclinical Investigations in Detecting Inflammation in Children and Adolescents with Obesity and Metabolic Syndrome.","authors":"Mihaela-Andreea Podeanu, Ștefănița Bianca Vintilescu, Claudiu Marinel Ionele, Raluca Elena Sandu, Carmen Elena Niculescu, Mirela-Marinela Florescu, Mioara Desdemona Stepan","doi":"10.3390/life14091206","DOIUrl":null,"url":null,"abstract":"Obesity is linked to the increasing prevalence of metabolic syndrome (MetS), even among the pediatric population. Some inflammatory and cardioembolic indexes derived from routine laboratory tests have captivated the attention of the medical community.Objectives: The aim of our study was to evaluate whether these markers are effective in distinguishing varying degrees of obesity and MetS in children and adolescents.Methods: We conducted a retrospective study. A total of 71 children and adolescents, aged between 6 and 16, were included in the study. Among them, 5 were overweight, 35 had obesity, and 31 had severe obesity. According to the NCEP ATP III criteria, 32 individuals had Metabolic Syndrome (MetS), while 39 did not have MetS.Results: The MetS positive group had higher values of TG/HDL-C (p < 0.001), TC/HDL-C (p < 0.001), MHR (p = 0.015), LHR (p = 0.001), NHR (p = 0.001), atherogenic index of plasma (p < 0.001), and PHR (p < 0.001). ESR, NLR, PLR, and SII did not progressively increase with the number of MetS criteria. The ROC curve analysis demonstrated that markers such as TG/HDL-C, the atherogenic index of plasma, TC/HDL-C, LHR, NHR, and PHR were effective in identifying MetS in children and adolescents with obesity.Conclusions: In conclusion, we determined that some novel inflammatory and cardioembolic indexes are useful in assessing MetS and obesity in children and adolescents.","PeriodicalId":56144,"journal":{"name":"Life-Basel","volume":null,"pages":null},"PeriodicalIF":3.2000,"publicationDate":"2024-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11433473/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Life-Basel","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.3390/life14091206","RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Obesity is linked to the increasing prevalence of metabolic syndrome (MetS), even among the pediatric population. Some inflammatory and cardioembolic indexes derived from routine laboratory tests have captivated the attention of the medical community.

Objectives: The aim of our study was to evaluate whether these markers are effective in distinguishing varying degrees of obesity and MetS in children and adolescents.

Methods: We conducted a retrospective study. A total of 71 children and adolescents, aged between 6 and 16, were included in the study. Among them, 5 were overweight, 35 had obesity, and 31 had severe obesity. According to the NCEP ATP III criteria, 32 individuals had Metabolic Syndrome (MetS), while 39 did not have MetS.

Results: The MetS positive group had higher values of TG/HDL-C (p < 0.001), TC/HDL-C (p < 0.001), MHR (p = 0.015), LHR (p = 0.001), NHR (p = 0.001), atherogenic index of plasma (p < 0.001), and PHR (p < 0.001). ESR, NLR, PLR, and SII did not progressively increase with the number of MetS criteria. The ROC curve analysis demonstrated that markers such as TG/HDL-C, the atherogenic index of plasma, TC/HDL-C, LHR, NHR, and PHR were effective in identifying MetS in children and adolescents with obesity.

Conclusions: In conclusion, we determined that some novel inflammatory and cardioembolic indexes are useful in assessing MetS and obesity in children and adolescents.

查看原文本刊更多论文

副临床检查在检测肥胖症和代谢综合征儿童和青少年炎症中的作用。

肥胖与代谢综合征（MetS）发病率的上升有关，甚至在儿童群体中也是如此。从常规实验室检测中得出的一些炎症和心肌栓塞指数引起了医学界的关注：我们的研究旨在评估这些指标是否能有效区分儿童和青少年不同程度的肥胖和 MetS：我们进行了一项回顾性研究。研究共纳入了 71 名 6 至 16 岁的儿童和青少年。其中，5 人超重，35 人肥胖，31 人严重肥胖。根据 NCEP ATP III 标准，32 人患有代谢综合征（MetS），39 人未患有代谢综合征：MetS阳性组的TG/HDL-C（p < 0.001）、TC/HDL-C（p < 0.001）、MHR（p = 0.015）、LHR（p = 0.001）、NHR（p = 0.001）、血浆致动脉粥样硬化指数（p < 0.001）和PHR（p < 0.001）值均较高。ESR、NLR、PLR和SII并没有随着MetS标准的增加而逐渐增加。ROC曲线分析表明，TG/HDL-C、血浆致动脉粥样硬化指数、TC/HDL-C、LHR、NHR和PHR等指标能有效识别肥胖儿童和青少年的MetS：总之，我们发现一些新型的炎症和心肌栓塞指数有助于评估儿童和青少年的 MetS 和肥胖症。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Life-Basel Biochemistry, Genetics and Molecular Biology-General Biochemistry,Genetics and Molecular Biology

CiteScore

4.30

自引率

6.20%

发文量

1798

审稿时长

11 weeks

期刊介绍： Life (ISSN 2075-1729) is an international, peer-reviewed open access journal of scientific studies related to fundamental themes in Life Sciences, especially those concerned with the origins of life and evolution of biosystems. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers.