Cardiometabolic comorbidities and cardiovascular events in "non-functioning" adrenal incidentalomas: a systematic review and meta-analysis.

IF 5.4 2区医学 Q1 Medicine

Journal of Endocrinological Investigation Pub Date : 2024-12-01 Epub Date: 2024-09-30 DOI:10.1007/s40618-024-02440-0

Vittoria Favero, Chiara Parazzoli, Davide Paolo Bernasconi, Iacopo Chiodini

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引用次数: 0

Abstract

Objective: Recent studies investigated the prevalence of arterial hypertension (AH), diabetes mellitus (DM) and/or prediabetes, dyslipidemia (DL), metabolic syndrome (MS) and cardiovascular events (CVE) in patients with non-functioning adrenal incidentalomas (NFAI). We aimed to investigate the available literature to determine the prevalence of AH, DM, DM and/or prediabetes (Composite DM, C-DM), DL, MS and CVE in patients with NFAI as compared to patients without adrenal incidentalomas (AI).

Design: Systematic review and meta-analysis.

Methods: A meta-analysis was performed using studies that evaluated the prevalence of AH, DM, C-DM, DL, MS and CVE in patients with NFAI versus matched subjects without AI. A random-effects model (DerSimonian and Laird) was used to calculate the pooled odds ratio (OR) and 95% Confidence Interval (95%CI) for each outcome.

Results: Among the 36 available studies, 19 studies provided the necessary data (4716 subjects, mean age 57.6 ± 4.6). The association between AH, DM, C-DM, DL, MS and CVE was reported in 18 (4546 subjects), 7 (1743 subjects), 5 (4315 subjects), 11 (3820 subjects), 8 (1170 subjects) and 5 (2972 subjects), respectively. The presence of NFAI was associated with AH (OR 1.87, 95%CI 1.39-2.51), C-DM (OR 2.04, 95%CI 1.70-2.45) and MS (OR 2.89, 95%CI 1.93-4.32), but not with DM, DL and CVE.

Conclusions: Patients with NFAI have higher prevalence of AH, C-DM and MS than control subjects without NFAI.

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无功能 "肾上腺偶发瘤的心脏代谢合并症和心血管事件：系统综述和荟萃分析。

研究目的最近的研究调查了非功能性肾上腺偶发瘤（NFAI）患者中动脉高血压（AH）、糖尿病（DM）和/或糖尿病前期、血脂异常（DL）、代谢综合征（MS）和心血管事件（CVE）的患病率。我们旨在对现有文献进行调查，以确定与无肾上腺偶发瘤（AI）患者相比，NFAI患者中AH、DM、DM和/或糖尿病前期（复合DM，C-DM）、DL、MS和CVE的患病率：设计：系统回顾和荟萃分析：荟萃分析使用了评估 NFAI 患者与无 AI 的匹配受试者中 AH、DM、C-DM、DL、MS 和 CVE 患病率的研究。研究采用随机效应模型（DerSimonian 和 Laird）计算每种结果的合计几率比（OR）和 95% 置信区间（95%CI）：在现有的 36 项研究中，19 项研究提供了必要的数据（4716 名受试者，平均年龄为 57.6 ± 4.6）。18项研究（4546名受试者）、7项研究（1743名受试者）、5项研究（4315名受试者）、11项研究（3820名受试者）、8项研究（1170名受试者）和5项研究（2972名受试者）分别报告了AH、DM、C-DM、DL、MS和CVE之间的关联。NFAI与AH（OR 1.87，95%CI 1.39-2.51）、C-DM（OR 2.04，95%CI 1.70-2.45）和MS（OR 2.89，95%CI 1.93-4.32）相关，但与DM、DL和CVE无关：结论：与无 NFAI 的对照组相比，NFAI 患者的 AH、C-DM 和 MS 患病率更高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Endocrinological Investigation ENDOCRINOLOGY & METABOLISM-

CiteScore

8.10

自引率

7.40%

发文量

242

期刊介绍： The Journal of Endocrinological Investigation is a well-established, e-only endocrine journal founded 36 years ago in 1978. It is the official journal of the Italian Society of Endocrinology (SIE), established in 1964. Other Italian societies in the endocrinology and metabolism field are affiliated to the journal: Italian Society of Andrology and Sexual Medicine, Italian Society of Obesity, Italian Society of Pediatric Endocrinology and Diabetology, Clinical Endocrinologists’ Association, Thyroid Association, Endocrine Surgical Units Association, Italian Society of Pharmacology.