The Impact of IgG Fc-Glycosylation on Disease Dynamics in Primary Sjögren's Disease- Insights from the Belgian Sjögren's Syndrome Transition Trial

IF 11.4 1区医学 Q1 RHEUMATOLOGY

Arthritis & Rheumatology Pub Date : 2024-09-29 DOI:10.1002/art.43018

Helena Achten, Leander Meuris, Liselotte Deroo, Matthias Jarlborg, Tine Decruy, Joke Deprez, Emilie Dumas, Kristel De Boeck, Eva Genbrugge, Wouter Bauters, Frederick Dochy, David Creytens, Dimitri Roels, Nico Callewaert, Dirk Elewaut, Isabelle Peene

引用次数: 0

Abstract

Glycans attached to the fragment crystallizable region (Fc) of IgG antibodies influence their pro- or anti-inflammatory effector function. We aimed to explore the interrelation between the Fc-glycosylation profile and disease transition, disease activity and outcome in patients with suspected and confirmed primary Sjögren's Disease (SjD).

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IgG Fc-糖基化对原发性斯约戈伦病病情动态的影响--比利时斯约戈伦综合征过渡试验的启示

附着在 IgG 抗体片段可结晶区（Fc）上的糖类会影响其促炎或抗炎效应功能。我们的目的是探索 Fc-糖基化特征与疑似和确诊原发性斯杰格林病（SjD）患者的疾病转归、疾病活动和预后之间的相互关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Arthritis & Rheumatology RHEUMATOLOGY-

CiteScore

20.90

自引率

3.00%

发文量

371

期刊介绍： Arthritis & Rheumatology is the official journal of the American College of Rheumatology and focuses on the natural history, pathophysiology, treatment, and outcome of rheumatic diseases. It is a peer-reviewed publication that aims to provide the highest quality basic and clinical research in this field. The journal covers a wide range of investigative areas and also includes review articles, editorials, and educational material for researchers and clinicians. Being recognized as a leading research journal in rheumatology, Arthritis & Rheumatology serves the global community of rheumatology investigators and clinicians.