Visible-Light-Mediated Trifluoroalkylation of Isoquinolines via Three-Component Minisci-Type Reaction

IF 5.4 3区材料科学 Q2 CHEMISTRY, PHYSICAL

ACS Applied Energy Materials Pub Date : 2024-09-30 DOI:10.1021/acs.orglett.4c03096

Ankita Thakur, Shiv Shankar Gupta, Sumit, Sachin, Upendra Sharma

引用次数: 0

Abstract

A sustainable photocatalytic approach has been established for trifluoroalkylation of isoquinoline via a three-component Minisci-type reaction using a green solvent. The polarity reversal radical cascade strategy renders the selective addition of an electrophilic CF₃ radical to an olefin to forge a nucleophilic C-centered radical. This multicomponent approach is operationally simple and environmentally benign with various functional groups, viz. aldehydes, acetals, amides, and halides. Mechanistic investigations were carried out to elaborate the reductive quenching catalytic pathway.

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可见光介导的通过三组分迷你型反应的异喹啉三氟烷基化反应

利用绿色溶剂，通过三组分 Minisci- 型反应，建立了一种可持续的光催化方法，用于异喹啉的三氟烷基化。极性反转自由基级联策略使亲电的 CF3 自由基与烯烃发生选择性加成反应，生成亲核的 C 中心自由基。这种多组分方法操作简单，对各种官能团（即醛、乙醛、酰胺和卤化物）的环境无害。为了详细说明还原淬火催化途径，我们进行了机理研究。

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来源期刊

ACS Applied Energy Materials Materials Science-Materials Chemistry

CiteScore

10.30

自引率

6.20%

发文量

1368

期刊介绍： ACS Applied Energy Materials is an interdisciplinary journal publishing original research covering all aspects of materials, engineering, chemistry, physics and biology relevant to energy conversion and storage. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrate knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important energy applications.