Lutein and zeaxanthin reduce neuronal cell damage caused by lipid peroxidation

IF 2.3 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biochemistry and Biophysics Reports Pub Date : 2024-09-27 DOI:10.1016/j.bbrep.2024.101835

Satoshi Morita, Toshiaki Sueyasu, Hisanori Tokuda, Yoshihisa Kaneda, Takayuki Izumo, Yoshihiro Nakao

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Abstract

Oxidative stress and lipid peroxide levels in the brain increase with aging. The carotenoids lutein and zeaxanthin have potent antioxidant properties and the ability to improve cognitive function. However, their effects on neuronal damage via lipid peroxidation remain unknown. Therefore, we aimed to elucidate the effects of these carotenoids on neuronal damage induced by accumulated peroxidized lipids. We developed an oxidative stress model of lipid peroxidation-induced neuronal damage using differentiated neuronal cells derived from human neuroblastoma SH-SY5Y cells in vitro. Combining rotenone and RSL3 increased mitochondrial oxidative stress and lipid reactive oxygen species (ROS), which resulted in enhanced neuronal damage. Lutein and zeaxanthin were added to the cells for 1 week, and these carotenoids suppressed mitochondrial oxidative stress and lipid peroxidation in differentiated neuronal cells and mitigated neuronal damage. Further investigation is required to clarify the underlying pathways in detail.

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叶黄素和玉米黄质可减少脂质过氧化对神经细胞造成的损伤

随着年龄的增长，大脑中的氧化应激和过氧化脂质含量也会增加。类胡萝卜素叶黄素和玉米黄质具有强大的抗氧化特性，能够改善认知功能。然而，它们通过脂质过氧化对神经元损伤的影响仍然未知。因此，我们旨在阐明这些类胡萝卜素对累积过氧化脂质诱导的神经元损伤的影响。我们利用从人类神经母细胞瘤 SH-SY5Y 细胞中分化出来的神经元细胞，在体外建立了脂质过氧化诱导神经元损伤的氧化应激模型。将鱼藤酮和 RSL3 结合使用会增加线粒体氧化应激和脂质活性氧（ROS），从而导致神经元损伤加剧。在细胞中添加叶黄素和玉米黄质一周后，这些类胡萝卜素抑制了分化神经元细胞的线粒体氧化应激和脂质过氧化反应，减轻了神经元损伤。要详细阐明其潜在的途径，还需要进一步的研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biochemistry and Biophysics Reports Biochemistry, Genetics and Molecular Biology-Biophysics

CiteScore

4.60

自引率

0.00%

发文量

191

审稿时长

59 days

期刊介绍： Open access, online only, peer-reviewed international journal in the Life Sciences, established in 2014 Biochemistry and Biophysics Reports (BB Reports) publishes original research in all aspects of Biochemistry, Biophysics and related areas like Molecular and Cell Biology. BB Reports welcomes solid though more preliminary, descriptive and small scale results if they have the potential to stimulate and/or contribute to future research, leading to new insights or hypothesis. Primary criteria for acceptance is that the work is original, scientifically and technically sound and provides valuable knowledge to life sciences research. We strongly believe all results deserve to be published and documented for the advancement of science. BB Reports specifically appreciates receiving reports on: Negative results, Replication studies, Reanalysis of previous datasets.