The role(s) of NF-Y in development and differentiation

IF 13.7 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Cell Death and Differentiation Pub Date : 2024-09-26 DOI:10.1038/s41418-024-01388-1

Diletta Dolfini, Carol Imbriano, Roberto Mantovani

引用次数: 0

Abstract

NF-Y is a conserved sequence-specific trimeric Transcription Factor -TF- binding to the CCAAT element. We review here the role(s) in development, from pre-implantation embryo to terminally differentiated tissues, by rationalizing and commenting on genetic, genomic, epigenetic and biochemical studies. This effort brings to light the impact of NF-YA isoforms on stemness and differentiation, as well as binding to distal vs promoter proximal sites and connections with selected TFs.

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NF-Y 在发育和分化中的作用

NF-Y 是一种保守的序列特异性三聚体转录因子 -TF- 与 CCAAT 元件结合。我们在此通过对遗传学、基因组学、表观遗传学和生物化学研究的梳理和评论，回顾了 NF-Y 在从胚胎植入前到终末分化组织的发育过程中的作用。这项工作揭示了 NF-YA 异构体对干性和分化的影响，以及与远端和启动子近端位点的结合以及与选定 TF 的联系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell Death and Differentiation 生物-生化与分子生物学

CiteScore

24.70

自引率

1.60%

发文量

181

审稿时长

3 months

期刊介绍： Mission, vision and values of Cell Death & Differentiation: To devote itself to scientific excellence in the field of cell biology, molecular biology, and biochemistry of cell death and disease. To provide a unified forum for scientists and clinical researchers It is committed to the rapid publication of high quality original papers relating to these subjects, together with topical, usually solicited, reviews, meeting reports, editorial correspondence and occasional commentaries on controversial and scientifically informative issues.