Tissue Mechanics and Hedgehog Signaling Crosstalk as a Key Epithelial–Stromal Interplay in Cancer Development (Adv. Sci. 35/2024)

IF 14.3 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Advanced Science Pub Date : 2024-09-26 DOI:10.1002/advs.202470210

Shanika Karunasagara, Ali Taghizadeh, Sang-Hyun Kim, So Jung Kim, Yong-Jae Kim, Mohsen Taghizadeh, Moon-Young Kim, Kyu-Young Oh, Jung-Hwan Lee, Hye Sung Kim, Jeongeun Hyun, Hae-Won Kim

引用次数: 0

Abstract

Cancer Cells' Mastery of Their Environment

Cancer cells actively reshape their surroundings. By releasing sonic hedgehog, they stiffen the extracellular matrix, enlisting stromal cells as allies. This increased stiffness heightens actomyosin cytoskeleton tension, activating oncogenic transcription factors and driving invasive tumor growth. More details can be found in article number 2400063 by Jeongeun Hyun, Hae-Won Kim, and co-workers.

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组织力学和刺猬信号串扰是癌症发展过程中上皮-基质相互作用的关键（科学进展报告 35/2024）

癌细胞对环境的掌控癌细胞积极重塑周围环境。通过释放声刺猬，癌细胞使细胞外基质变硬，并将基质细胞视为盟友。这种增强的硬度会提高肌动蛋白细胞骨架的张力，激活致癌转录因子，推动肿瘤的侵袭性生长。更多详情请见 Jeongeun Hyun、Hae-Won Kim 及合作者撰写的文章 2400063。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advanced Science CHEMISTRY, MULTIDISCIPLINARYNANOSCIENCE &-NANOSCIENCE & NANOTECHNOLOGY

CiteScore

18.90

自引率

2.60%

发文量

1602

审稿时长

1.9 months

期刊介绍： Advanced Science is a prestigious open access journal that focuses on interdisciplinary research in materials science, physics, chemistry, medical and life sciences, and engineering. The journal aims to promote cutting-edge research by employing a rigorous and impartial review process. It is committed to presenting research articles with the highest quality production standards, ensuring maximum accessibility of top scientific findings. With its vibrant and innovative publication platform, Advanced Science seeks to revolutionize the dissemination and organization of scientific knowledge.