The link between traumatic stress and autoimmune rheumatic diseases: A systematic scoping review

IF 4.6 2区医学 Q1 RHEUMATOLOGY

Seminars in arthritis and rheumatism Pub Date : 2024-09-21 DOI:10.1016/j.semarthrit.2024.152558

Markus Ploesser , Stuart Silverman , Jose Daniel Lomeli Diaz , Miriam Tanja Zincke , Mihaela B. Taylor

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引用次数: 0

Abstract

Background

The impact of traumatic stress on autoimmune rheumatic diseases (ARDs) has been largely overlooked in existing research. This scoping review aimed to systematically examine the research literature relating to the relationship between traumatic stress and ARDs, by identifying study designs, methodologies, and gaps in the current research landscape.

Methods

The following databases and search interfaces were searched on 15th December 2023: Embase (via Embase.com), Medline (via PubMed), and Web of Science. Additional references were identified via bibliographies of included studies. The following studies were included, with no publication date limit and language restricted to English: targeting the association between traumatic stress and ARDs, observational methodologies, including cohort, case-control, and cross-sectional studies, exclusively focusing on self-reported psychological trauma impacts, such as adverse childhood experiences (ACEs), Post-traumatic Stress Disorder (PTSD), or major life stressors. Two authors independently assessed the studies for inclusion criteria and extracted the data.

Results

This scoping review revealed connections between traumatic stress and ARDs through an analysis of 21 included studies, highlighting the scarcity of research in this area. The studies, primarily from high-income countries and especially the USA, span from 2000 to 2023, indicating a growing interest in recent years and employing a range of methodologies. Traumas such as ACEs, PTSD, and major life events were frequently examined, showing a strong association with an increased risk and severity of ARDs, particularly rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE).

Conclusion

This scoping review reveals a notable dearth in research on the impact of traumatic stress, such as ACEs, PTSD, and major life events, on ARDs, especially on rare diseases, yet underscores a significant association between trauma and ARD severity or incidence. It highlights the critical need for future investigations to broaden the scope of ARDs studied, extend research to less represented regions, and utilize diverse, standardized methodologies to deepen our understanding of the trauma-ARD association.

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创伤压力与自身免疫性风湿病之间的联系：系统性范围审查

背景现有研究在很大程度上忽视了创伤应激对自身免疫性风湿病（ARD）的影响。本范围综述旨在通过确定研究设计、方法和当前研究中的空白点，系统地审查与创伤应激和 ARDs 之间关系有关的研究文献。方法于 2023 年 12 月 15 日检索了以下数据库和检索界面：于 2023 年 12 月 15 日检索了以下数据库和检索界面：Embase（通过 Embase.com）、Medline（通过 PubMed）和 Web of Science。通过所纳入研究的参考书目确定了其他参考文献。纳入的研究没有出版日期限制，语言仅限于英语：针对创伤压力与 ARDs 之间的关联，采用观察法，包括队列、病例对照和横断面研究，专门关注自我报告的心理创伤影响，如不良童年经历 (ACE)、创伤后应激障碍 (PTSD) 或主要生活压力源。两位作者独立评估了研究的纳入标准并提取了数据。结果该范围综述通过对 21 项纳入研究的分析，揭示了创伤压力与 ARDs 之间的联系，凸显了该领域研究的稀缺性。这些研究主要来自高收入国家，尤其是美国，时间跨度从 2000 年到 2023 年，表明近年来人们对该领域的研究兴趣日益浓厚，并采用了多种研究方法。ACE、创伤后应激障碍和重大生活事件等创伤经常被研究，这些创伤与 ARD（尤其是类风湿性关节炎（RA）和系统性红斑狼疮（SLE））风险和严重程度的增加有着密切的联系。该研究强调，未来的调查亟需扩大所研究的急性损伤性关节炎的范围，将研究扩展到代表性较低的地区，并利用多样化、标准化的方法加深我们对创伤与急性损伤性关节炎关系的理解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Seminars in arthritis and rheumatism 医学-风湿病学

CiteScore

9.20

自引率

4.00%

发文量

176

审稿时长

46 days

期刊介绍： Seminars in Arthritis and Rheumatism provides access to the highest-quality clinical, therapeutic and translational research about arthritis, rheumatology and musculoskeletal disorders that affect the joints and connective tissue. Each bimonthly issue includes articles giving you the latest diagnostic criteria, consensus statements, systematic reviews and meta-analyses as well as clinical and translational research studies. Read this journal for the latest groundbreaking research and to gain insights from scientists and clinicians on the management and treatment of musculoskeletal and autoimmune rheumatologic diseases. The journal is of interest to rheumatologists, orthopedic surgeons, internal medicine physicians, immunologists and specialists in bone and mineral metabolism.