How the somatosensory system adapts to the motor change in Stroke: A hemispheric Shift?

IF 2.1 4区医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Medical hypotheses Pub Date : 2024-09-24 DOI:10.1016/j.mehy.2024.111487

Jordan N. Williamson , Beni Mulyana , Rita Huan-Ting Peng , Sanjiv Jain , Wael Hassaneen , Amrendra Miranpuri , Yuan Yang

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Abstract

Previous studies found that post-stroke motor impairments are associated with damage to the lesioned corticospinal tract and a maladaptive increase in indirect contralesional motor pathways. How the somatosensory system adapts to the change in the use of motor pathways and the role of adaptive sensory feedback to the abnormal movement control of the paretic arm remains largely unknown. We hypothesize that following a unilateral stroke, there is an adaptive hemispheric shift of somatosensory processing toward the contralesional sensorimotor areas to provide sensory feedback support to the contralesional indirect motor pathways. This research could provide new insights related to somatosensory reorganization after stroke, which could enrich future hypothesis-driven therapeutic rehabilitation strategies from a sensory or sensory-motor perspective. Understanding how somatosensory information shifts may provide a target for a novel method to therapeutically prevent and mitigate the emergence and expression of upper limb motor impairments, following a stroke.

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体感系统如何适应中风患者的运动变化？半球转移？

以往的研究发现，中风后的运动障碍与病变的皮质脊髓束受损以及间接对侧运动通路的不适应性增加有关。躯体感觉系统如何适应运动通路使用的变化，以及适应性感觉反馈对瘫痪手臂异常运动控制的作用，在很大程度上仍是未知数。我们假设，单侧中风后，躯体感觉处理会向对侧感觉运动区进行半球适应性转移，为对侧间接运动通路提供感觉反馈支持。这项研究可以为中风后的躯体感觉重组提供新的见解，从而从感觉或感觉运动的角度丰富未来的假设驱动治疗康复策略。了解躯体感觉信息是如何转移的，可以为预防和减轻中风后上肢运动障碍的出现和表现的新方法提供治疗目标。

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来源期刊

Medical hypotheses 医学-医学：研究与实验

CiteScore

10.60

自引率

2.10%

发文量

167

审稿时长

60 days

期刊介绍： Medical Hypotheses is a forum for ideas in medicine and related biomedical sciences. It will publish interesting and important theoretical papers that foster the diversity and debate upon which the scientific process thrives. The Aims and Scope of Medical Hypotheses are no different now from what was proposed by the founder of the journal, the late Dr David Horrobin. In his introduction to the first issue of the Journal, he asks ''what sorts of papers will be published in Medical Hypotheses? and goes on to answer ''Medical Hypotheses will publish papers which describe theories, ideas which have a great deal of observational support and some hypotheses where experimental support is yet fragmentary''. (Horrobin DF, 1975 Ideas in Biomedical Science: Reasons for the foundation of Medical Hypotheses. Medical Hypotheses Volume 1, Issue 1, January-February 1975, Pages 1-2.). Medical Hypotheses was therefore launched, and still exists today, to give novel, radical new ideas and speculations in medicine open-minded consideration, opening the field to radical hypotheses which would be rejected by most conventional journals. Papers in Medical Hypotheses take a standard scientific form in terms of style, structure and referencing. The journal therefore constitutes a bridge between cutting-edge theory and the mainstream of medical and scientific communication, which ideas must eventually enter if they are to be critiqued and tested against observations.