Sensitization to latex and food allergens in atopic dermatitis patients according to ALEX2 Allergy Xplorer test

IF 3.2 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecular immunology Pub Date : 2024-09-25 DOI:10.1016/j.molimm.2024.09.002

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引用次数: 0

Abstract

Aim of our study is to analyse the sensitisation profile to molecular components of latex and of food allergens with the use of ALEX2 Allergy Xplorer test and to compare these results with the anamnestical data after latex exposure and with the anamnestical data after exposure to food allergens in atopic dermatitis patients.

Methods

100 patients were included in the study (49 men and 51 women with the average age 40.6 years). The specific IgE was examined with the use of ALEX2 Allergy Xplorer test. A detailed personal history of allergic reaction to latex and allergic reaction to food allergens was taken in all included patients.

Results

The sensitisation to latex was recorded in 17 % of patients, majority of patients have positive results of specific IgE to Hev b 8 without clinical reaction to latex. In 7 % of patients with positive results of specific IgE to Hev b 1, Hev b 3, Hev b 5, Hev b 6.02 and Hev b 11 the contact urticaria or contact dermatitis were recorded. The latex fruit syndrome was recorded in 7 % of patients; in another 10 % of patients we recorded no clinical reaction to latex, but the positive results to molecular components of latex and the clinical symptoms after ingestion of different kinds of fruits.

Conclusion

The significant relation between the results of specific IgE to molecular components Hev b 3, Hev b 5 and Hev b 6.02 and the clinical reaction to latex was confirmed; these components significantly imply clinical reactivity to latex.

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根据 ALEX2 Allergy Xplorer 测试，特应性皮炎患者对乳胶和食物过敏原的致敏情况

我们的研究旨在使用 ALEX2 Allergy Xplorer 测试分析特应性皮炎患者对乳胶和食物过敏原分子成分的过敏情况，并将这些结果与特应性皮炎患者接触乳胶后的过敏反应数据以及接触食物过敏原后的过敏反应数据进行比较。使用 ALEX2 Allergy Xplorer 检测仪检测特异性 IgE。结果有 17% 的患者对乳胶过敏，大多数患者对 Hev b 8 的特异性 IgE 呈阳性，但对乳胶没有临床反应。在对 Hev b 1、Hev b 3、Hev b 5、Hev b 6.02 和 Hev b 11 的特异性 IgE 呈阳性结果的患者中，有 7% 出现了接触性荨麻疹或接触性皮炎。有 7% 的患者出现了乳胶水果综合征；另有 10% 的患者对乳胶没有临床反应，但对乳胶分子成分的检测结果呈阳性，并且在摄入不同种类的水果后出现了临床症状。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular immunology 医学-免疫学

CiteScore

6.90

自引率

2.80%

发文量

324

审稿时长

50 days

期刊介绍： Molecular Immunology publishes original articles, reviews and commentaries on all areas of immunology, with a particular focus on description of cellular, biochemical or genetic mechanisms underlying immunological phenomena. Studies on all model organisms, from invertebrates to humans, are suitable. Examples include, but are not restricted to: Infection, autoimmunity, transplantation, immunodeficiencies, inflammation and tumor immunology Mechanisms of induction, regulation and termination of innate and adaptive immunity Intercellular communication, cooperation and regulation Intracellular mechanisms of immunity (endocytosis, protein trafficking, pathogen recognition, antigen presentation, etc) Mechanisms of action of the cells and molecules of the immune system Structural analysis Development of the immune system Comparative immunology and evolution of the immune system "Omics" studies and bioinformatics Vaccines, biotechnology and therapeutic manipulation of the immune system (therapeutic antibodies, cytokines, cellular therapies, etc) Technical developments.