Spinal cord injury: pathophysiology and principles of management

Q4 Medicine

Orthopaedics and Trauma Pub Date : 2024-08-26 DOI:10.1016/j.mporth.2024.07.002

Simon B Roberts, Athanasios I Tsirikos

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引用次数: 0

Abstract

Spinal cord injury (SCI) is a catastrophic neurological condition resulting in increased physical dependency, medical comorbidity, psychological distress and economic burden. New SCI affects 250,000–500,000 individuals globally each year. The pathophysiological mechanisms following SCI are incompletely understood, and the management of patients following SCI is challenging. Understanding the evolution of pathophysiological changes following SCI is fundamental to delivering and developing appropriate management strategies. Timely interventions following acute SCI can prevent secondary neurological deterioration and improve potential for neurological recovery. A bespoke, multidisciplinary and holistic approach to the management and rehabilitation of SCI patients can optimize physical and mental wellbeing and maximize patient's neurological recovery and functional capabilities. Current therapeutic options following SCI are limited and do not overcome the debilitating effects of SCI. Current knowledge of the pathophysiological mechanism following SCI, management strategies and novel therapies for adult and paediatric SCI patients are reviewed.

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脊髓损伤：病理生理学和处理原则

脊髓损伤（SCI）是一种灾难性的神经系统疾病，会增加身体依赖性、医疗并发症、心理困扰和经济负担。全球每年新增脊髓损伤患者达 25 万至 50 万人。人们对 SCI 后的病理生理机制尚不完全了解，对 SCI 患者的管理也极具挑战性。了解 SCI 后病理生理变化的演变是提供和制定适当管理策略的基础。急性 SCI 后及时干预可防止继发性神经功能恶化，并提高神经功能恢复的可能性。为 SCI 患者量身定制的多学科综合管理和康复方法可以优化患者的身心健康，最大限度地提高患者的神经康复和功能能力。目前对 SCI 患者的治疗方案有限，无法克服 SCI 造成的衰弱影响。本文回顾了目前对 SCI 后的病理生理机制、成人和儿童 SCI 患者的管理策略和新型疗法的了解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Orthopaedics and Trauma Medicine-Orthopedics and Sports Medicine

CiteScore

1.00

自引率

0.00%

发文量

期刊介绍： Orthopaedics and Trauma presents a unique collection of International review articles summarizing the current state of knowledge and research in orthopaedics. Each issue focuses on a specific topic, discussed in depth in a mini-symposium; other articles cover the areas of basic science, medicine, children/adults, trauma, imaging and historical review. There is also an annotation, self-assessment questions and a second opinion section. In this way the entire postgraduate syllabus will be covered in a 4-year cycle.