Advancements in screening systems for active ingredients in traditional Chinese medicines using ligand fishing technique

IF 11.8 1区化学 Q1 CHEMISTRY, ANALYTICAL

Trends in Analytical Chemistry Pub Date : 2024-09-21 DOI:10.1016/j.trac.2024.117983

Yi Qin , Ying Yan , Jie Zhou , Xun Gao , Longshan Zhao , Xuefeng Guan

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引用次数: 0

Abstract

Natural products have been a significant source of lead compounds in modern drug discovery. Compared to traditional techniques for active ingredient screening, affinity-based ligand fishing offers decent specificity, high efficiency, simplicity of operation, and high throughput. In recent years, this technique has been developed and successfully used to screen bioactive chemicals from natural products, making it the most practical and successful method for screening specific ligands from complex matrices. The strategy of "ligand fishing" has been summarized in this paper based on recent publications. The separation principles of ligand fishing for the screening and identification of active ingredients in traditional Chinese medicines (TCMs) using various analytical techniques were reviewed. In addition, based on the deficiencies of current drug discovery approaches, the future development of various new methodologies to screen for active compounds from TCMs were reviewed. These new methodologies have the potential to facilitate faster and more effective drug development.

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利用配体钓技术筛选中药活性成分系统的进展

天然产物一直是现代药物发现中先导化合物的重要来源。与传统的活性成分筛选技术相比，基于亲和力的配体钓法具有特异性强、效率高、操作简单、通量大等特点。近年来，这一技术已被开发并成功用于从天然产物中筛选生物活性化学物质，成为从复杂基质中筛选特异配体的最实用、最成功的方法。本文根据最近发表的论文总结了 "配体捕获 "的策略。综述了利用各种分析技术筛选和鉴定中药有效成分的配体捕获分离原理。此外，基于当前药物发现方法的不足，本文还综述了未来从中药中筛选活性化合物的各种新方法的发展。这些新方法有可能促进更快、更有效的药物开发。

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来源期刊

Trends in Analytical Chemistry 化学-分析化学

CiteScore

20.00

自引率

4.60%

发文量

257

审稿时长

3.4 months

期刊介绍： TrAC publishes succinct and critical overviews of recent advancements in analytical chemistry, designed to assist analytical chemists and other users of analytical techniques. These reviews offer excellent, up-to-date, and timely coverage of various topics within analytical chemistry. Encompassing areas such as analytical instrumentation, biomedical analysis, biomolecular analysis, biosensors, chemical analysis, chemometrics, clinical chemistry, drug discovery, environmental analysis and monitoring, food analysis, forensic science, laboratory automation, materials science, metabolomics, pesticide-residue analysis, pharmaceutical analysis, proteomics, surface science, and water analysis and monitoring, these critical reviews provide comprehensive insights for practitioners in the field.