Expanded gray matter atrophy with severity stages of adult comorbid insomnia and sleep apnea

IF 3.8 2区医学 Q1 CLINICAL NEUROLOGY

Sleep medicine Pub Date : 2024-09-18 DOI:10.1016/j.sleep.2024.09.027

Liping Pan , Hui Li , Jiawei Guo , Chao Ma , Liming Li , Wenfeng Zhan , Huiyu Chen , Yuting Wu , Guihua Jiang , Shumei Li

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引用次数: 0

Abstract

Objective

To investigate gray matter volume (GMV) changes in patients with comorbid insomnia and sleep apnea (COMISA) of differing severity and relationships between GMV alterations and clinical measures.

Methods

Thirty-four COMISA patients and 24 healthy controls (HC) were recruited. All patients underwent structural MRI and completed measures related to respiration, sleep, mood, and cognition. COMISA patients were further divided into a mild and moderate COMISA (MC) and a severe COMISA (SC) group. Changes in GMV of COMISA patients were investigated via VBM. The voxel-wise differences in GMV were compared between HC group and COMISA group. Analysis of covariance (ANCOVA) was performed on individual GMV maps in MC, SC, and HC groups to further investigate effects of different stages of COMISA severity on GMV. Partial correlation analysis was then performed to analyze relationships between altered GMV and clinical measures.

Results

GMV atrophy was mainly located in the temporal lobes and fusiform gyrus in COMISA group. The post-hoc analysis of the ANCOVA revealed temporal lobes and fusiform gyrus atrophy in MC and SC groups compared to HC and the temporal lobe atrophy was expanded in SC group based on cluster size. Moreover, the SC group showed GMV atrophy of the right amygdala compared to both MC and HC groups. Partial correlation analysis revealed positive relationships between the GMV and mood-and cognitive-related measures and negative correlation between GMV and respiration measure.

Conclusions

Our findings showed GMV atrophy expansion from temporal lobe to limbic system (right amygdala) as severity stages increase in COMISA patients. These findings contribute to our understanding of neurobiological mechanisms underlying different stages of severity in COMISA patients.

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灰质萎缩扩大与成人合并失眠和睡眠呼吸暂停的严重程度有关

方法招募 34 名 COMISA 患者和 24 名健康对照组（HC）。所有患者均接受了结构性核磁共振成像检查，并完成了与呼吸、睡眠、情绪和认知相关的测量。COMISA患者被进一步分为轻度和中度COMISA（MC）组以及重度COMISA（SC）组。通过 VBM 研究了 COMISA 患者 GMV 的变化。比较了 HC 组和 COMISA 组 GMV 的体素差异。对 MC 组、SC 组和 HC 组的单个 GMV 图进行协方差分析（ANCOVA），以进一步研究 COMISA 严重程度的不同阶段对 GMV 的影响。结果GMV萎缩主要位于COMISA组的颞叶和纺锤形回。方差分析的事后分析表明，与 HC 相比，MC 组和 SC 组的颞叶和纺锤形回萎缩，且根据聚类大小，SC 组的颞叶萎缩范围扩大。此外，与 MC 组和 HC 组相比，SC 组显示右侧杏仁核 GMV 萎缩。我们的研究结果表明，随着 COMISA 患者病情严重程度的增加，GMV 萎缩范围从颞叶扩展到边缘系统（右侧杏仁核）。这些发现有助于我们了解COMISA患者不同严重阶段的神经生物学机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Sleep medicine 医学-临床神经学

CiteScore

8.40

自引率

6.20%

发文量

1060

审稿时长

49 days

期刊介绍： Sleep Medicine aims to be a journal no one involved in clinical sleep medicine can do without. A journal primarily focussing on the human aspects of sleep, integrating the various disciplines that are involved in sleep medicine: neurology, clinical neurophysiology, internal medicine (particularly pulmonology and cardiology), psychology, psychiatry, sleep technology, pediatrics, neurosurgery, otorhinolaryngology, and dentistry. The journal publishes the following types of articles: Reviews (also intended as a way to bridge the gap between basic sleep research and clinical relevance); Original Research Articles; Full-length articles; Brief communications; Controversies; Case reports; Letters to the Editor; Journal search and commentaries; Book reviews; Meeting announcements; Listing of relevant organisations plus web sites.