CDK5 affects the resistance of lung cancer to radiotherapy by altering the tumor microenvironment

IF 1.7 4区综合性期刊 Q2 MULTIDISCIPLINARY SCIENCES

Journal of Radiation Research and Applied Sciences Pub Date : 2024-09-22 DOI:10.1016/j.jrras.2024.101104

Hua-Fei Chen , Chun-Wei Xu , Wen-Xian Wang , Puen Chen , Xiao-Feng Li , Gang Lan , Zhan-Qiang Zhai , You-Cai Zhu , Kai-Qi Du , Li-Chao Huang

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Abstract

This article aims to explore the impact of cyclin-dependent kinase 5 (CDK5) on the tumor microenvironment and its influence on radiotherapy resistance in lung cancer through bioinformatics analysis. Initially, dataset GSE148532 identifying 517 differentially expressed genes, with 67 downregulated and 450 upregulated. Functional enrichment analysis revealed these genes are primarily concentrated in the extracellular matrix. KEGG analysis indicated significant enrichment in the TGF-beta signaling pathway and cytokine-cytokine receptor interactions. Using Cytoscape, three key networks and the top ten intermediary genes were identified. Immune infiltration analysis showed significant correlations between CDK5 expression and macrophages, neutrophils, and dendritic cells.

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CDK5 通过改变肿瘤微环境影响肺癌对放疗的耐受性

本文旨在通过生物信息学分析，探讨细胞周期蛋白依赖性激酶5（CDK5）对肿瘤微环境的影响及其对肺癌放疗耐药的影响。最初，数据集GSE148532鉴定出517个差异表达基因，其中67个下调，450个上调。功能富集分析显示，这些基因主要集中在细胞外基质中。KEGG 分析表明，TGF-beta 信号通路和细胞因子-细胞因子受体相互作用中存在大量富集基因。利用 Cytoscape，确定了三个关键网络和前十个中间基因。免疫浸润分析表明，CDK5的表达与巨噬细胞、中性粒细胞和树突状细胞之间存在显著相关性。

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来源期刊

Journal of Radiation Research and Applied Sciences MULTIDISCIPLINARY SCIENCES-

自引率

5.90%

发文量

130

审稿时长

16 weeks

期刊介绍： Journal of Radiation Research and Applied Sciences provides a high quality medium for the publication of substantial, original and scientific and technological papers on the development and applications of nuclear, radiation and isotopes in biology, medicine, drugs, biochemistry, microbiology, agriculture, entomology, food technology, chemistry, physics, solid states, engineering, environmental and applied sciences.