The correlation between patients with type 2 diabetes mellitus and chronic microvascular complications during the glucose peak time

IF 2.9 3区医学 Q3 ENDOCRINOLOGY & METABOLISM

Journal of diabetes and its complications Pub Date : 2024-09-17 DOI:10.1016/j.jdiacomp.2024.108866

Yanqiu Jiang , Xinlei Wang , Xiaoqin Zhao , Yi Sun , Ping Huang , Qianfeng Que , Rongfeng Shi , Xuying Zhao , Honghong Lu , Yunjuan Gu

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Abstract

Introduction

To assess the Type 2 Diabetes Mellitus (T2DM) patients in association with Chronic Microvascular Complications at Glucose Peak Time and the association among chronic microvascular complications in T2DM patients and the glucose peak period in the typical steamed bread meal test.

Methods

Overall 1095 T2DM patients were classified as three groups: (1) Group G1: glucose peak time ≤ 1 h (n = 84), Group G2: 1 h < glucose peak time ≤ 2 h (n = 648) and Group G3: glucose peak time > 2 h (n = 363). The clinical characteristics, insulin characteristics and glucose peak time and chronic microvascular complications markers of patients in each group was analyzed and compared. Statistical analyses were performed using SPSS 23.0, employing chi-square tests, Kruskal-Wallis tests, one-way ANOVA, and binary logistic regression analysis, with significance set at P < 0.05.

Results

Age, length of disease, glycated hemoglobin (HbA1c), urine albumin-creatinine ratio (UACR), and the number of patients with diabetic retinopathy (DR) increased (all P < 0.05) in those with postponed glucose peak time, while insulinogenic indexes, the AUC for C-p (AUCC-p), fasting, and 120-min C-peptide (C-p) decreased (all P < 0.05). Only age was connected to patients with diabetic kidney disease (DKD) independently in binary logistic regression analysis, although delayed glucose peak time was related to the presence of patients with DR. (all P < 0.05).

Conclusion

Delayed glucose peak time contributed to DR. Attention should be paid to condition of chronic microvascular complications in T2DM patients with a postponed peak glucose timing.

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2 型糖尿病患者与血糖高峰期慢性微血管并发症的相关性

简介：目的评估 2 型糖尿病（T2DM）患者在血糖峰值时间与慢性微血管并发症的关系，以及 T2DM 患者慢性微血管并发症与典型馒头餐试验中血糖峰值时间的关系。方法将1095名T2DM患者分为三组：(1) G1组：血糖峰值时间≤1 h（n = 84），G2组：1 h < 血糖峰值时间≤2 h（n = 648），G3组：血糖峰值时间 > 2 h（n = 363）。对各组患者的临床特征、胰岛素特征、血糖峰值时间和慢性微血管并发症指标进行分析和比较。使用 SPSS 23.0 进行统计分析，采用卡方检验、Kruskal-Wallis 检验、单因素方差分析和二元逻辑回归分析，显著性以 P < 0.05 为标准。结果血糖峰值时间推迟者的年龄、病程、糖化血红蛋白（HbA1c）、尿白蛋白-肌酐比值（UACR）和糖尿病视网膜病变（DR）患者人数增加（均为 P < 0.05），而胰岛素生成指数、C-p 的 AUC（AUCC-p）、空腹和 120 分钟 C 肽（C-p）降低（均为 P < 0.05）。在二元逻辑回归分析中，只有年龄与糖尿病肾病（DKD）患者独立相关，但葡萄糖峰值时间延迟与是否存在 DR 患者相关（均为 P < 0.05）。应注意血糖峰值时间推迟的 T2DM 患者的慢性微血管并发症情况。

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来源期刊

Journal of diabetes and its complications 医学-内分泌学与代谢

CiteScore

5.90

自引率

3.30%

发文量

153

审稿时长

16 days

期刊介绍： Journal of Diabetes and Its Complications (JDC) is a journal for health care practitioners and researchers, that publishes original research about the pathogenesis, diagnosis and management of diabetes mellitus and its complications. JDC also publishes articles on physiological and molecular aspects of glucose homeostasis. The primary purpose of JDC is to act as a source of information usable by diabetes practitioners and researchers to increase their knowledge about mechanisms of diabetes and complications development, and promote better management of people with diabetes who are at risk for those complications. Manuscripts submitted to JDC can report any aspect of basic, translational or clinical research as well as epidemiology. Topics can range broadly from early prediabetes to late-stage complicated diabetes. Topics relevant to basic/translational reports include pancreatic islet dysfunction and insulin resistance, altered adipose tissue function in diabetes, altered neuronal control of glucose homeostasis and mechanisms of drug action. Topics relevant to diabetic complications include diabetic retinopathy, neuropathy and nephropathy; peripheral vascular disease and coronary heart disease; gastrointestinal disorders, renal failure and impotence; and hypertension and hyperlipidemia.