AuNP@Self-assembled 4H-Chromene-Enhanced colorimetric detection of ganciclovir using smartphone Technology: Portable solutions for healthcare

Abstract

Any substance, radiation, or radionuclide in our environment that promotes carcinogenesis is a cancerogen. In the current work, we modified the 4H-chromene derivative by covering its surface with a shell of gold nanoparticles. Interestingly, ganciclovir (GCV) formed a bridge between the Nap-group of 4H-chromene and gold nanoparticles to display surface charge reduction properties in AuNP@Self-assembled 4H-Chromene. The surface charge of AuNPs is reduced as a result of the electron transfer mechanism brought on by the creation of the Nap-GCV-AuNP link, which leads to agglomeration. This led to the development of a dual-mode colorimetric sensor for GCV that incorporates solution form and portable sensor strip. The probe showed a linear range of 0–74 nM under ideal circumstances, with a detection limit of 4 nM in solution and 3 nM on paper strip detection. An evaluation of the practical utility in human serum using a portable visual read-out produced satisfactory findings, with a recovery percentage of 102.1 % and a standard deviation of ± 4 %. Surprisingly, this is the first work on the colorimetric detection of Ganciclovir that we are aware of.