Multifunctional Bi2S3-Au nanoclusters for fluorescence/infrared thermal imaging guided photothermal therapy

IF 5.2 2区医学 Q1 PHARMACOLOGY & PHARMACY

International Journal of Pharmaceutics: X Pub Date : 2024-09-17 DOI:10.1016/j.ijpx.2024.100286

Hongmei Sun , Yuyu Cao , Beibei Zhai , Xiaoshuang Zhao , Xuejun Zhang , Jiangtao Su

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引用次数: 0

Abstract

Nanotechnology has attracted extensive attention in the diagnosis and treatment of cancer. Therefore, the research aimed at developing new nanomaterials and exploring their applications in biomedicine has attracted more attention. In this study, Bi₂S₃-Au nanoclusters (Bi₂S₃-AuNCs) as fluorescence/infrared thermal imaging-guided photothermal therapy (PTT) was prepared for the first time. It was achieved in a facile and mild way by optimizing the amount of Bi³⁺ and Au³⁺ using bovine serum albumin (BSA) as reducer and stabilizer. The as-prepared Bi₂S₃-AuNCs with special morphology showed high stability, excellent biocompatibility and good photostability. Apart from these, it also can accumulate at tumor sites and exhibit considerable fluorescence/infrared thermal imaging-guided PTT. Bi₂S₃-AuNCs nanoparticles integrate imaging and therapeutic functions into an advanced application platform, which provides the possibility to build a novel nano-cancer diagnosis and treatment platform.

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用于荧光/红外热成像引导光热疗法的多功能 Bi2S3-Au 纳米团簇

纳米技术在癌症诊断和治疗方面引起了广泛关注。因此，旨在开发新型纳米材料并探索其在生物医学中的应用的研究引起了更多关注。本研究首次制备了作为荧光/红外热成像引导的光热疗法（PTT）的 Bi2S3-Au 纳米团簇（Bi2S3-AuNCs）。该研究以牛血清白蛋白（BSA）作为还原剂和稳定剂，通过优化 Bi3+ 和 Au3+ 的用量，以简便、温和的方法实现了这一目标。制备出的具有特殊形貌的 Bi2S3-AuNCs 具有高稳定性、优异的生物相容性和良好的光稳定性。除此以外，它还能在肿瘤部位积聚，并在荧光/红外热成像引导下显示出可观的 PTT。Bi2S3-AuNCs 纳米粒子集成像和治疗功能于一体，是一种先进的应用平台，为构建新型纳米癌症诊断和治疗平台提供了可能。

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来源期刊

International Journal of Pharmaceutics: X Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science

CiteScore

6.60

自引率

0.00%

发文量

审稿时长

24 days

期刊介绍： International Journal of Pharmaceutics: X offers authors with high-quality research who want to publish in a gold open access journal the opportunity to make their work immediately, permanently, and freely accessible. International Journal of Pharmaceutics: X authors will pay an article publishing charge (APC), have a choice of license options, and retain copyright. Please check the APC here. The journal is indexed in SCOPUS, PUBMED, PMC and DOAJ. The International Journal of Pharmaceutics is the second most cited journal in the "Pharmacy & Pharmacology" category out of 358 journals, being the true home for pharmaceutical scientists concerned with the physical, chemical and biological properties of devices and delivery systems for drugs, vaccines and biologicals, including their design, manufacture and evaluation. This includes evaluation of the properties of drugs, excipients such as surfactants and polymers and novel materials. The journal has special sections on pharmaceutical nanotechnology and personalized medicines, and publishes research papers, reviews, commentaries and letters to the editor as well as special issues.